Literature DB >> 7905295

Transmitter release and presynaptic Ca2+ currents blocked by the spider toxin omega-Aga-IVA.

D A Protti1, O D Uchitel.   

Abstract

Mammalian neuromuscular transmission is resistant to L and N type calcium channel blockers but very sensitive to a low molecular weight funnel web spider venom toxin, FTX, which selectively blocks P type calcium channels. To further characterize the calcium channels involved in neuromuscular transmission we studied the effect of omega Agatoxin (omega-Aga-IVA) a polypeptide P type channel blocker from the same spider venom. We show that omega-Aga-IVA is a potent and irreversible inhibitor of the presynaptic Ca2+ currents and of acetylcholine release induced by electrical stimulation or by K+ depolarization. This provides further evidences that transmitter release at the mammalian neuromuscular junction is mediated by P type Ca2+ channels.

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Year:  1993        PMID： 7905295     DOI： 10.1097/00001756-199312000-00039

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  34 in total

1.  Calcium channels involved in the inhibition of acetylcholine release by presynaptic muscarinic receptors in rat striatum.

Authors:  V Dolezal; S Tucek
Journal:  Br J Pharmacol       Date:  1999-08       Impact factor: 8.739

2.  Active zone density is conserved during synaptic growth but impaired in aged mice.

Authors:  Jie Chen; Takafumi Mizushige; Hiroshi Nishimune
Journal:  J Comp Neurol       Date:  2012-02-01       Impact factor: 3.215

Review 3.  Molecular mechanism of active zone organization at vertebrate neuromuscular junctions.

Authors:  Hiroshi Nishimune
Journal:  Mol Neurobiol       Date:  2011-12-02       Impact factor: 5.590

4.  Modulation of calcium currents is eliminated after cleavage of a strategic component of the mammalian secretory apparatus.

Authors:  Eugene M Silinsky
Journal:  J Physiol       Date:  2005-06-16       Impact factor: 5.182

5.  Methylmercury decreases cellular excitability by a direct blockade of sodium and calcium channels in bovine chromaffin cells: an integrative study.

Authors:  J Fuentes-Antrás; E Osorio-Martínez; M Ramírez-Torres; I Colmena; J C Fernández-Morales; J M Hernández-Guijo
Journal:  Pflugers Arch       Date:  2013-07-03       Impact factor: 3.657

6.  Selective disruption of the mammalian secretory apparatus enhances or eliminates calcium current modulation in nerve endings.

Authors:  Eugene M Silinsky
Journal:  Proc Natl Acad Sci U S A       Date:  2008-04-17       Impact factor: 11.205

7.  Calcium channel subtypes contributing to acetylcholine release from normal, 4-aminopyridine-treated and myasthenic syndrome auto-antibodies-affected neuromuscular junctions.

Authors:  F Giovannini; E Sher; R Webster; J Boot; B Lang
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

8.  Effects of Ca2+ channel blockers on transmitter release and presynaptic currents at the frog neuromuscular junction.

Authors:  E Katz; P A Ferro; B D Cherksey; M Sugimori; R Llinás; O D Uchitel
Journal:  J Physiol       Date:  1995-08-01       Impact factor: 5.182

9.  Decreased calcium currents in motor nerve terminals of mice with Lambert-Eaton myasthenic syndrome.

Authors:  D O Smith; M W Conklin; P J Jensen; W D Atchison
Journal:  J Physiol       Date:  1995-08-15       Impact factor: 5.182

10.  Characterization of rhythmic Ca2+ transients in early embryonic chick motoneurons: Ca2+ sources and effects of altered activation of transmitter receptors.

Authors:  Sheng Wang; Luis Polo-Parada; Lynn T Landmesser
Journal:  J Neurosci       Date:  2009-12-02       Impact factor: 6.167
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