| Literature DB >> 7904483 |
W H Meetze1, V Shenoy, G Martin, P Musy, J Neu.
Abstract
The ontogeny of small intestinal glutaminase (GA) and glutamine synthetase (GS) was studied with relation to the maternal administration of dexamethasone (DEX). Pregnant Sprague-Dawley rats were administered 0.2 mg/kg of DEX or saline twice daily on days 19 and 20 of gestation. Activity of GA did not increase from the fetus to the 10-day-old rat; however, GS activity increased 7-fold. DEX induced doubling of GA activity and mRNA, but only a slight increase is GS activity and mRNA was observed in the fetus. GA and GS activities appear to be regulated by different mechanisms.Entities:
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Year: 1993 PMID： 7904483 DOI： 10.1159/000244013
Source DB: PubMed Journal: Biol Neonate ISSN： 0006-3126