Literature DB >> 7904457

Identification of a new DNA polymorphism tightly linked to DQ-alpha locus.

P Gasparini1, A Bonizzato, A Totaro, L Zelante.   

Abstract

Utilizing Alu-polymerase chain reaction and single-strand conformation polymorphism technologies a new DNA restriction fragment length polymorphism was detected on a cosmid clone located on chromosome 6p21. An accurate analysis of allele frequency was carried out on a large series of unrelated individuals. Furthermore a detailed linkage analysis in several large pedigrees showed this new polymorphism to be tightly linked to the HLA-DQ alpha locus.

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Year:  1993        PMID: 7904457

Source DB:  PubMed          Journal:  Exp Clin Immunogenet        ISSN: 0254-9670


  1 in total

1.  The motilin gene: subregional localisation, tissue expression, DNA polymorphisms and exclusion as a candidate gene for the HLA-associated immotile cilia syndrome.

Authors:  P Gasparini; A Grifa; S Savasta; I Merlo; L Bisceglia; A Totaro; L Zelante
Journal:  Hum Genet       Date:  1994-12       Impact factor: 4.132

  1 in total

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