Literature DB >> 7904075

Excitotoxic neuronal damage and neuropsychiatric disorders.

C F Zorumski1, J W Olney.   

Abstract

Excitatory amino acids (EAA) serve important physiological functions in the vertebrate CNS, including participation in fast excitatory synaptic transmission, modulation of synaptic plasticity and regulation of neuronal morphology during development. However, paradoxically they also harbor neurotoxic (excitotoxic) potential, which, if unleashed, can cause widespread degeneration of CNS neurons. Accumulating evidence suggests a role for excitotoxins in a variety of human neuropsychiatric disorders. This paper reviews the classes of EAA receptors in the CNS, the mechanisms underlying EAA-mediated neuronal damage and the role of EAA in specific human disorders.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 7904075     DOI： 10.1016/0163-7258(93)90043-d

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  15 in total

Review 1.  Neural activity and survival in the developing nervous system.

Authors:  S Mennerick; C F Zorumski
Journal:  Mol Neurobiol       Date:  2000 Aug-Dec       Impact factor: 5.590

Review 2.  NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders.

Authors:  Charles F Zorumski; Yukitoshi Izumi
Journal:  Neurosci Biobehav Rev       Date:  2012-01-02       Impact factor: 8.989

Review 3.  Homeostatic regulation of glutamate release in response to depolarization.

Authors:  Krista L Moulder; Julian P Meeks; Steven Mennerick
Journal:  Mol Neurobiol       Date:  2006-04       Impact factor: 5.590

4.  Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults.

Authors:  Joshua Hogins; Devon C Crawford; Xiaoping Jiang; Steven Mennerick
Journal:  Neurobiol Dis       Date:  2011-05-14       Impact factor: 5.996

5.  Analysis of glutamate receptors in primary cultured neurons from fetal rat forebrain.

Authors:  J Oillet; F Nicolas; V Koziel; J L Daval
Journal:  Neurochem Res       Date:  1995-06       Impact factor: 3.996

6.  In vivo detection of postictal perturbations of cerebral metabolism by use of proton MR spectroscopy: preliminary results in a canine model of prolonged generalized seizures.

Authors:  R Neppl; C M Nguyen; W Bowen; T Al-Saadi; J Pallagi; G Morris; W Mueller; R Johnson; R Prost; S D Rand
Journal:  AJNR Am J Neuroradiol       Date:  2001 Nov-Dec       Impact factor: 3.825

Review 7.  The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy.

Authors:  Alistair J Barber; Thomas W Gardner; Steven F Abcouwer
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-02-28       Impact factor: 4.799

8.  S-nitrosylation of mixed lineage kinase 3 contributes to its activation after cerebral ischemia.

Authors:  Shu-Qun Hu; Jun-Song Ye; Yan-Yan Zong; Chang-Cheng Sun; Dong-Hai Liu; Yong-Ping Wu; Tao Song; Guang-Yi Zhang
Journal:  J Biol Chem       Date:  2011-11-28       Impact factor: 5.157

9.  Characteristics of hippocampal glycine release in cell-damaging conditions in the adult and developing mouse.

Authors:  P Saransaari; S S Oja
Journal:  Neurochem Res       Date:  2001-07       Impact factor: 3.996

10.  GM1 ganglioside attenuates the development of vacuous chewing movements induced by long-term haloperidol treatment of rats.

Authors:  O A Andreassen; H A Jørgensen
Journal:  Psychopharmacology (Berl)       Date:  1994-12       Impact factor: 4.530
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.