Literature DB >> 7903438

Pituitary adenylate cyclase activating peptide and vasoactive intestinal polypeptide: differentiation effects on human neuroblastoma NB-OK-1 cells.

M Hoshino1, M Li, L Q Zheng, M Suzuki, T Mochizuki, N Yanaihara.   

Abstract

Pituitary adenylate cyclase activating peptide-38 (PACAP-38), PACAP-27 and vasoactive intestinal polypeptide (VIP) increased intracellular cAMP content in human neuroblastoma NB-OK-1 cells transiently. PACAP and VIP also arrested cell growth and induced morphological differentiation, which lasted for 24 h in spite of removal of PACAP-38 and PACAP-27. The order of potencies for the neurite outgrowth and the arrest of cell growth is PACAP-38 > PACAP-27 > VIP. The results suggest the possibility that these neuropeptides are new candidates for differentiation activity.

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Year:  1993        PMID： 7903438     DOI： 10.1016/0304-3940(93)90792-j

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  5 in total

1.  Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells.

Authors:  Jacqueline Hill; Shyue-An Chan; Barbara Kuri; Corey Smith
Journal:  J Biol Chem       Date:  2011-10-18       Impact factor: 5.157

Review 2.  VIP as a cell-growth and differentiation neuromodulator role in neurodevelopment.

Authors:  J M Muller; V Lelievre; L Becq-Giraudon; A C Meunier
Journal:  Mol Neurobiol       Date:  1995 Apr-Jun       Impact factor: 5.590

3.  Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development.

Authors:  D Vaudry; B J Gonzalez; M Basille; A Fournier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-03       Impact factor: 11.205

4.  Differential coupling of the PAC1 SV1 splice variant on human colonic tumors to the activation of intracellular cAMP but not intracellular Ca2+ does not activate tumor proliferation.

Authors:  Patrizia M Germano; Sang V Le; David S Oh; Robert Fan; Sandy Lieu; Alan Siu; Joseph R Pisegna
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

5.  Cloning and characterization of the signal transduction of four splice variants of the human pituitary adenylate cyclase activating polypeptide receptor. Evidence for dual coupling to adenylate cyclase and phospholipase C.

Authors:  J R Pisegna; S A Wank
Journal:  J Biol Chem       Date:  1996-07-19       Impact factor: 5.157
  5 in total

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