Literature DB >> 7903060

Synthesis of a [11C]methoxy derivative of alpha-dihydrotetrabenazine: a radioligand for studying the vesicular monoamine transporter.

J N DaSilva1, M R Kilbourn, T J Mangner.   

Abstract

The synthesis of [11C]TBZOMe, a [11C]methoxy derivative at the 2-hydroxy position of alpha-dihydrotetrabenazine, was carried out by an O-[11C]methylation reaction. The product [11C]TBZOMe (100-200 mCi) was obtained in 15-40% radiochemical yield (corrected for decay) within 37 min, and in high specific activity (2000-2500 Ci/mmol) and radiochemical purity (> 97%). [11C]TBZOMe is a potential new radioligand for studying the vesicular monoamine transporter using positron emission tomography.

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Year:  1993        PMID： 7903060     DOI： 10.1016/0969-8043(93)90103-h

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  12 in total

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Authors:  Falk W Lohoff; John P Dahl; Thomas N Ferraro; Steven E Arnold; Jürgen Gallinat; Thomas Sander; Wade H Berrettini
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Review 4.  Vesicular monoamine transporter 2: role as a novel target for drug development.

Authors:  Guangrong Zheng; Linda P Dwoskin; Peter A Crooks
Journal:  AAPS J       Date:  2006-11-10       Impact factor: 4.009

Review 5.  Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry.

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6.  Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.

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Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-12-04       Impact factor: 9.236

7.  A Purification Method of 18F-FP-(+)-DTBZ via Solid-Phase Extraction With Combined Cartridges.

Authors:  Yuyin Dai; Ri Sa; Feng Guan; Qi Wang; Yinghua Li; Hongguang Zhao
Journal:  Front Med (Lausanne)       Date:  2021-07-09

8.  [11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.

Authors:  Susan R Criswell; Susan Searles Nielsen; Mark N Warden; Joel S Perlmutter; Stephen M Moerlein; Lianne Sheppard; Jason Lenox-Krug; Harvey Checkoway; Brad A Racette
Journal:  J Occup Environ Med       Date:  2020-10       Impact factor: 2.306

9.  A Functional Vesicular Monoamine Transporter 1 (VMAT1) Gene Variant Is Associated with Affect and the Prevalence of Anxiety, Affective, and Alcohol Use Disorders in a Longitudinal Population-Representative Birth Cohort Study.

Authors:  Mariliis Vaht; Evelyn Kiive; Toomas Veidebaum; Jaanus Harro
Journal:  Int J Neuropsychopharmacol       Date:  2016-07-05       Impact factor: 5.176

Review 10.  Imaging pancreatic islet cells by positron emission tomography.

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