Literature DB >> 7902541

Prostacyclin (PGI2) protects rat cortical neurons in culture against hypoxia/reoxygenation and glutamate-induced injury.

C Cazevieille1, A Muller, C Bonne.   

Abstract

Arachidonic acid and its metabolites are released in brain extracellular fluids as a result of ischemia and may participate in either damaging or protecting neural tissues. This study investigates the neuroprotective effect of prostacyclin (PGI2) on hypoxia (5 h)/reoxygenation (3 h) and on the excitotoxic neurotransmitter, glutamate (10 microM), in rat cortical neuron cultures. At microM concentrations, PGI2 inhibits lactate dehydrogenase release, a cell-injury marker. These results, showing a direct cytoprotective effect of PGI2 on brain cells, reinforce its beneficial properties on vessels and circulating cells in cerebral ischemia.

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Year:  1993        PMID： 7902541     DOI： 10.1016/0304-3940(93)90924-a

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

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Authors:  A O Caggiano; R P Kraig
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2.  Endothelium-derived hyperpolarizing factor in the brain: influence of sex, vessel size and disease state.

Authors:  Catherine M Davis; Dominic A Siler; Nabil J Alkayed
Journal:  Womens Health (Lond)       Date:  2011-05

3.  Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1.

Authors:  L Minghetti; A Nicolini; E Polazzi; A Greco; M Perretti; L Parente; G Levi
Journal:  Br J Pharmacol       Date:  1999-03       Impact factor: 8.739

4.  Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death.

Authors:  Ava L Taylor; Joseph V Bonventre; Tracy F Uliasz; James A Hewett; Sandra J Hewett
Journal:  J Neurochem       Date:  2008-06-28       Impact factor: 5.372

5.  Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in hypertensive rats.

Authors:  Hideki Ito; Ayako Hashimoto; Yutaka Matsumoto; Hiroshi Yao; Goro Miyakoda
Journal:  J Cereb Blood Flow Metab       Date:  2009-10-07       Impact factor: 6.200

6.  Putative role of prostaglandin receptor in intracerebral hemorrhage.

Authors:  Shekher Mohan; Abdullah S Ahmad; Alexander V Glushakov; Chase Chambers; Sylvain Doré
Journal:  Front Neurol       Date:  2012-10-22       Impact factor: 4.003

7.  Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after spinal cord demyelination.

Authors:  C Takahashi; R Muramatsu; H Fujimura; H Mochizuki; T Yamashita
Journal:  Cell Death Dis       Date:  2013-09-12       Impact factor: 8.469
  7 in total

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