| Literature DB >> 7900978 |
F J Luan1.
Abstract
A multidrug-resistant cell line K562/A02 was obtained from its parent K562 by long-term adriamycin (ADM) induction and cloning selection. The K562/A02 has high expression of mdr-1 P-glycoprotein (P170), strong resistance to its induction drug ADM and some other anticancer drugs such as daunorubicin, VP16, homoharringtonine and amsacrine. Its intracellular concentration of daunorubicin is much lower than that in its parent K562, which can be partially reversed by cyclosporin-A and verapamil.Entities:
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Year: 1993 PMID： 7900978
Source DB: PubMed Journal: Zhonghua Zhong Liu Za Zhi ISSN： 0253-3766