Serum marker for hepatic fibrosis and related liver pathology.

A close correlation has been demonstrated between levels of various serum markers for hepatic fibrosis and related liver pathological changes by determination of serum extracellular matrix components and immune electron microscopic studies of the liver in various hepatic diseases. Our studies indicated that serum laminin level is a useful marker for evaluating the degree of hepatic fibrosis and serum hyaluronate is a good marker for the diagnosis of liver cirrhosis by evaluating the degree of sinusoidal capillarization.