Literature DB >> 7898776

Metabotropic glutamate receptor-induced disinhibition is mediated by reduced transmission at excitatory synapses onto interneurons and inhibitory synapses onto pyramidal cells.

M A Desai1, C J McBain, J A Kauer, P J Conn.   

Abstract

Previous studies suggest that activation of metabotropic glutamate receptors (mGluRs) reduces GABA-mediated synaptic inhibition in area CA1 of the hippocampus. However, the mechanisms involved in this disinhibition are not known. We report that mGluR activation reduces both the GABAA and GABAB receptor-mediated components of evoked inhibitory postsynaptic potentials (IPSPs) by reducing transmission at excitatory synapses onto inhibitory interneurons and inhibitory synapses onto CA1 pyramidal cells.

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Year:  1994        PMID： 7898776     DOI： 10.1016/0304-3940(94)90564-9

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  11 in total

1.  G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses.

Authors:  Alex J Straiker; Catherine R Borden; Jane M Sullivan
Journal:  J Neurosci       Date:  2002-04-01       Impact factor: 6.167

2.  Neuronal glutamate uptake Contributes to GABA synthesis and inhibitory synaptic strength.

Authors:  Gregory C Mathews; Jeffrey S Diamond
Journal:  J Neurosci       Date:  2003-03-15       Impact factor: 6.167

3.  NMDA receptor dependence of mGlu-mediated depression of synaptic transmission in the CA1 region of the rat hippocampus.

Authors:  J Harvey; M J Palmer; A J Irving; V R Clarke; G L Collingridge
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

4.  Differential metabotropic glutamate receptor expression and modulation in two neocortical inhibitory networks.

Authors:  Qian-Quan Sun; Zhi Zhang; Yuanyuan Jiao; Chunzhao Zhang; Gábor Szabó; Ferenc Erdelyi
Journal:  J Neurophysiol       Date:  2009-02-25       Impact factor: 2.714

5.  Endogenous activation of metabotropic glutamate receptors modulates GABAergic transmission to gonadotropin-releasing hormone neurons and alters their firing rate: a possible local feedback circuit.

Authors:  Zhiguo Chu; Suzanne M Moenter
Journal:  J Neurosci       Date:  2005-06-15       Impact factor: 6.167

6.  Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.

Authors:  G Mannaioni; M J Marino; O Valenti; S F Traynelis; P J Conn
Journal:  J Neurosci       Date:  2001-08-15       Impact factor: 6.167

7.  The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats.

Authors:  Xia Li; Eliot L Gardner; Zheng-Xiong Xi
Journal:  Neuropharmacology       Date:  2007-11-19       Impact factor: 5.250

8.  GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission.

Authors:  Christian Patenaude; C Andrew Chapman; Sandrine Bertrand; Patrice Congar; Jean-Claude Lacaille
Journal:  J Physiol       Date:  2003-09-08       Impact factor: 5.182

9.  Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity.

Authors:  Tue G Banke; Georgi Gegelashvili
Journal:  J Physiol       Date:  2008-09-04       Impact factor: 5.182

10.  Evidence for metabotropic glutamate receptor activation in the induction of depolarization-induced suppression of inhibition in hippocampal CA1.

Authors:  W Morishita; S A Kirov; B E Alger
Journal:  J Neurosci       Date:  1998-07-01       Impact factor: 6.167
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