Literature DB >> 7898701

Cytochrome c oxidase in Alzheimer's disease brain: purification and characterization.

W D Parker1, J K Parks.   

Abstract

Cytochrome c oxidase (COX) is deficient in both peripheral tissue and brain of Alzheimer's disease (AD) patients and may be of pathogenic significance in AD. We purified COX from AD brains (n = 3) and control brains (n = 3) and characterized the enzyme kinetically and spectrally. Purified AD brain COX displayed anomalous kinetic behavior compared with control brain COX in that the low Km binding site was kinetically unidentifiable. For purposes of comparison, we purified COX from a standard beef heart preparation and found normal kinetic behavior. AD brain COX may be structurally abnormal and may make an important contribution to the bioenergetic defect seen in AD.

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Year:  1995        PMID： 7898701     DOI： 10.1212/wnl.45.3.482

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  51 in total

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Review 3.  Role of mitochondrial homeostasis and dynamics in Alzheimer's disease.

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Journal:  Neurobiol Dis       Date:  2012-01-10       Impact factor: 5.996

4.  Unraveling the role of metal ions and low catalytic activity of cytochrome C oxidase in Alzheimer's disease.

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5.  PET sheds light on Alzheimer's disease genetic risk.

Authors:  Russell H Swerdlow
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Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-29       Impact factor: 11.205

Review 9.  Mitochondrial Dysfunction and Synaptic Transmission Failure in Alzheimer's Disease.

Authors:  Lan Guo; Jing Tian; Heng Du
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Review 10.  Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention.

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