Literature DB >> 7898455

Cellular ADP-ribosylation of elongation factor 2.

W J Iglewski1.   

Abstract

A cellular ADP-ribosyltransferase activity has been found in a variety of animals and tissues. The enzyme transfers ADP-ribose from NAD to elongation factor 2, inactivating the factor and thus inhibiting in vitro protein synthesis. Although, the mechanism of action of the cellular enzyme appears similar to diphtheria toxin and Pseudomonas exotoxin A, it differs from the toxins in that only a fraction of the EF-2 pool is modified. The endogenously ADP-ribosylated EF-2 has been detected by a variety of methods including two-dimensional electrophoresis and immunoprecipitation with elongation factor 2 antibody. The nature of the cellular ADP-ribosyltransferase and its physiological significance are unknown.

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Year:  1994        PMID： 7898455     DOI： 10.1007/bf00928454

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  21 in total

Review 1.  Diphtheria toxin: mode of action and structure.

Authors:  R J Collier
Journal:  Bacteriol Rev       Date:  1975-03

2.  Reduced levels of ADP-ribosylatable elongation factor-2 in aged and SV40-transformed human cell cultures.

Authors:  B Riis; S I Rattan; A Derventzi; B F Clark
Journal:  FEBS Lett       Date:  1990-06-18       Impact factor: 4.124

3.  ADP-ribosylatable content of elongation factor-2 changes during cell cycle of normal and cancerous human cells.

Authors:  B Riis; S I Rattan; J Cavallius; B F Clark
Journal:  Biochem Biophys Res Commun       Date:  1989-03-31       Impact factor: 3.575

4.  Effect of diphtheria toxin on protein synthesis: inactivation of one of the transfer factors.

Authors:  R J Collier
Journal:  J Mol Biol       Date:  1967-04-14       Impact factor: 5.469

5.  Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2.

Authors:  N J Oppenheimer; J W Bodley
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157

6.  Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients.

Authors:  H C Palfrey; A C Nairn; L L Muldoon; M L Villereal
Journal:  J Biol Chem       Date:  1987-07-15       Impact factor: 5.157

7.  Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo.

Authors:  B H Iglewski; P V Liu; D Kabat
Journal:  Infect Immun       Date:  1977-01       Impact factor: 3.441

8.  Characterization of the endogenous ADP-ribosylation of wild-type and mutant elongation factor 2 in eukaryotic cells.

Authors:  J L Fendrick; W J Iglewski; J M Moehring; T J Moehring
Journal:  Eur J Biochem       Date:  1992-04-01

9.  Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

Authors:  A C Nairn; H C Palfrey
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

10.  Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.

Authors:  H Lee; W J Iglewski
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 12.779
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  4 in total

1.  Endogenous ADP-ribosylation of proteins in Mycobacterium smegmatis.

Authors:  M H Serres; J C Ensign
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

Review 2.  The plant translational apparatus.

Authors:  K S Browning
Journal:  Plant Mol Biol       Date:  1996-10       Impact factor: 4.076

3.  The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.

Authors:  Doris Jäger; Ursula Müller-Werdan; Klaus Pönicke; Jürgen Holtz; Karl Werdan; Sylvana P Müller
Journal:  Mol Cell Biochem       Date:  2002-01       Impact factor: 3.396

4.  Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A.

Authors:  Susan P Yates; Allan R Merrill
Journal:  Biochem J       Date:  2004-05-01       Impact factor: 3.766
  4 in total

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