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Literature DB >> 7898403

Induction of heat shock protein 70 and glial fibrillary acidic protein in the postischemic gerbil hippocampus.

T Araki¹, H Kato, X H Liu, K Kogure, Y Itoyama.

Abstract

Immunohistochemical changes of heat shock protein 70 (HSP 70) and glial fibrillary acidic protein (GFAP) were investigated in the gerbil hippocampus 1 h-7 days after 10 min of cerebral ischemia. Transient cerebral ischemia caused HSP 70 expression in GFAP-positive astrocytes in a delayed fashion, as compared with a rapid induction in vulnerable neurons such as hilar neurons. The present results may offer clues to elucidate the mechanisms of ischemic neuronal damage.

Entities: Disease Gene

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Year: 1994 PMID： 7898403 DOI： 10.1007/bf02098883

Source DB: PubMed Journal: Metab Brain Dis ISSN： 0885-7490 Impact factor: 3.584

16 in total

1. 70-kilodalton heat shock protein induction in cerebellar astrocytes and cerebellar granule cells in vitro: comparison with immunocytochemical localization after hyperthermia in vivo.

Authors: A M Marini; M Kozuka; R H Lipsky; T S Nowak
Journal: J Neurochem Date: 1990-05 Impact factor: 5.372

2. Comparison of the heat shock response in cultured cortical neurons and astrocytes.

Authors: R N Nishimura; B E Dwyer; K Clegg; R Cole; J de Vellis
Journal: Brain Res Mol Brain Res Date: 1991-01

3. Induced tolerance to ischemia in gerbil hippocampal neurons.

Authors: T Kirino; Y Tsujita; A Tamura
Journal: J Cereb Blood Flow Metab Date: 1991-03 Impact factor: 6.200

4. Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction.

Authors: F R Sharp; D Lowenstein; R Simon; K Hisanaga
Journal: J Cereb Blood Flow Metab Date: 1991-07 Impact factor: 6.200

5. Synthesis of a stress protein following transient ischemia in the gerbil.

Authors: T S Nowak
Journal: J Neurochem Date: 1985-11 Impact factor: 5.372

6. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia.

Authors: R Schmidt-Kastner; J Szymas; K A Hossmann
Journal: Neuroscience Date: 1990 Impact factor: 3.590

7. Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein.

Authors: C K Petito; I A Halaby
Journal: Int J Dev Neurosci Date: 1993-04 Impact factor: 2.457

Induction of heat shock protein 70 and glial fibrillary acidic protein in the postischemic gerbil hippocampus.

1. 70-kilodalton heat shock protein induction in cerebellar astrocytes and cerebellar granule cells in vitro: comparison with immunocytochemical localization after hyperthermia in vivo.

2. Comparison of the heat shock response in cultured cortical neurons and astrocytes.

3. Induced tolerance to ischemia in gerbil hippocampal neurons.

4. Heat shock protein hsp72 induction in cortical and striatal astrocytes and neurons following infarction.

5. Synthesis of a stress protein following transient ischemia in the gerbil.

6. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia.

7. Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic protein.

8. Delayed neuronal death in the gerbil hippocampus following ischemia.

9. Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.

10. Localization of 70-kDa stress protein induction in gerbil brain after ischemia.

1. Ribonuclease improves the state of hippocampal sections in the post-ischemic period.