Literature DB >> 7895167

Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain.

B F Daniels1, M C Nakamura, S D Rosen, W M Yokoyama, W E Seaman.   

Abstract

Ly-49A+ murine natural killer (NK) cells cannot lyse target cells that express H-2Dd. We demonstrate a functional requirement for carbohydrate recognition by Ly-49A. Treatment of H-2Dd+ target cells with tunicamycin prevents their binding to Ly-49A+ cells and renders them susceptible to lysis by Ly-49A+ NK cells. Fucoidan, a sulfated polysaccharide, binds to Ly-49A in a calcium-dependent manner, and this binding is inhibited by monosaccharides, particularly sulfated hexoses. The inactivation of Ly-49A+ NK cells by H-2Dd+ target cells is reversed in the presence of glucose 6-SO4. These results indicate that Ly-49A has a functional carbohydrate recognition domain and that target expression of carbohydrates alters their susceptibility to natural killing.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7895167     DOI： 10.1016/s1074-7613(94)80020-0

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  14 in total

1.  H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1.

Authors:  M R Daws; M Eriksson; L Oberg; A Ullén; C L Sentman
Journal:  Immunology       Date:  1999-08       Impact factor: 7.397

2.  Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.

Authors:  Jonathan Back; Anick Chalifour; Léonardo Scarpellino; Werner Held
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-26       Impact factor: 11.205

3.  Direct binding of a soluble natural killer cell inhibitory receptor to a soluble human leukocyte antigen-Cw4 class I major histocompatibility complex molecule.

Authors:  Q R Fan; D N Garboczi; C C Winter; N Wagtmann; E O Long; D C Wiley
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

Review 4.  The CD94/NKG2 C-type lectin receptor complex: involvement in NK cell-mediated recognition of HLA class I molecules.

Authors:  M López-Botet; M Carretero; J Pérez-Villar; T Bellón; M Llano; F Navarro
Journal:  Immunol Res       Date:  1997       Impact factor: 2.829

Review 5.  Natural killer cell receptors specific for major histocompatibility complex class I molecules.

Authors:  W M Yokoyama
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-11       Impact factor: 11.205

Review 6.  Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.

Authors:  R R Brutkiewicz; R M Welsh
Journal:  J Virol       Date:  1995-07       Impact factor: 5.103

7.  Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor.

Authors:  D N Burshtyn; A M Scharenberg; N Wagtmann; S Rajagopalan; K Berrada; T Yi; J P Kinet; E O Long
Journal:  Immunity       Date:  1996-01       Impact factor: 31.745

8.  Live Leishmania promastigotes can directly activate primary human natural killer cells to produce interferon-gamma.

Authors:  S Nylén; K Maasho; K Söderstrom; T Ilg; H Akuffo
Journal:  Clin Exp Immunol       Date:  2003-03       Impact factor: 4.330

9.  The Ly-49D receptor activates murine natural killer cells.

Authors:  L H Mason; S K Anderson; W M Yokoyama; H R Smith; R Winkler-Pickett; J R Ortaldo
Journal:  J Exp Med       Date:  1996-12-01       Impact factor: 14.307

10.  Recognition of class I major histocompatibility complex molecules by Ly-49: specificities and domain interactions.

Authors:  J Brennan; G Mahon; D L Mager; W A Jefferies; F Takei
Journal:  J Exp Med       Date:  1996-04-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.