| Literature DB >> 7895158 |
X Huang1, B Hultgren, N Dybdal, T A Stewart.
Abstract
The mechanism(s) leading to beta cell dysfunction in type I diabetes has not been defined. We have investigated whether islet expression of IFN alpha could be a cause of the lesions that are hallmarks of type I diabetes. Streptozotocin induces the expression of interferon-alpha by pancreatic islets prior to the diabetes induced by streptozotocin. Increased IFN alpha, induced by poly I/C or expressed from a transgene will exacerbate the diabetogenic effects of streptozotocin. In another rodent model of type I diabetes (the BB rat), islet expression of IFN alpha precedes lymphocytic infiltration and diabetes. As in the streptozotocin model, in the BB rats poly I/C will induce islet expression of IFN alpha and accelerate the onset of diabetes. These results are consistent with the hypothesis that islet expression of IFN alpha participates in causing type I diabetes.Entities:
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Year: 1994 PMID： 7895158 DOI： 10.1016/1074-7613(94)90089-2
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745