Literature DB >> 7895151

Distinct morphological and mito-inhibitory effects induced by TGF-beta 1, HGF and EGF on mouse, rat and human hepatocytes.

B Petersen1, C J Yee, W Bowen, R Zarnegar, G K Michalopoulos.   

Abstract

TGF-beta 1 is known as a potent inhibitor of proliferation of rat and human hepatocytes. In this study we show that the effects of TGF-beta 1 are quite different on mouse hepatocytes. In rat and human hepatocytes, TGF-beta 1 inhibited DNA synthesis and also inhibited the morphological changes induced by growth factors in rat and human hepatocytes. In contrast, addition of TGF-beta 1 to mouse hepatocytes resulted in pronounced alterations in morphology of these cells. These changes were similar to those induced by HGF and EGF. The induction of structural changes by TGF-beta 1 was noted only in mouse hepatocytes. Mouse hepatocytes were also much more resistant to the mito-inhibitory effect of TGF-beta 1. These findings suggest profound differences in hepatocyte growth regulation between these species and may relate to observed differences in susceptibility to carcinogenesis.

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Year:  1994        PMID： 7895151     DOI： 10.1007/bf00756762

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  40 in total

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Authors:  B I Carr; I Hayashi; E L Branum; H L Moses
Journal:  Cancer Res       Date:  1986-05       Impact factor: 12.701

5.  Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

Authors:  J R Merwin; W Newman; L D Beall; A Tucker; J Madri
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307

6.  Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels.

Authors:  G K Michalopoulos; W Bowen; A K Nussler; M J Becich; T A Howard
Journal:  J Cell Physiol       Date:  1993-09       Impact factor: 6.384

7.  Comparison of the biological actions of TGF beta-1 and TGF beta-2: differential activity in endothelial cells.

Authors:  J C Jennings; S Mohan; T A Linkhart; R Widstrom; D J Baylink
Journal:  J Cell Physiol       Date:  1988-10       Impact factor: 6.384

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Authors:  J E Klaunig; P J Goldblatt; D E Hinton; M M Lipsky; J Chacko; B F Trump
Journal:  In Vitro       Date:  1981-10

9.  Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

Authors:  T Masui; L M Wakefield; J F Lechner; M A LaVeck; M B Sporn; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  Distribution and modulation of the cellular receptor for transforming growth factor-beta.

Authors:  L M Wakefield; D M Smith; T Masui; C C Harris; M B Sporn
Journal:  J Cell Biol       Date:  1987-08       Impact factor: 10.539
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4.  Induction of apoptosis in mouse liver adenoma and carcinoma in vivo by transforming growth factor-beta1.

Authors:  Monika Chabicovsky; Ute Wastl; Henryk Taper; Bettina Grasl-Kraupp; Rolf Schulte-Hermann; Wilfried Bursch
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  4 in total

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