Literature DB >> 7893826

Regulation of heme-regulated eIF-2 alpha kinase and its expression in erythroid cells.

J J Chen1, J S Crosby, I M London.   

Abstract

In this article we focus first on the molecular mechanisms controlling the activity of the heme-regulated translational inhibitor, HRI, in erythroid cells. Then we discuss the tissue-specific expression of HRI. The experimental evidence obtained to date indicates that the major physiological role of HRI is in adjusting the synthesis of globin to the availability of heme.

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Year:  1994        PMID： 7893826     DOI： 10.1016/0300-9084(94)90080-9

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  10 in total

1.  Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.

Authors:  Darren J Perkins; Glen N Barber
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

2.  Lineage-specific SoxR-mediated Regulation of an Endoribonuclease Protects Non-enteric Bacteria from Redox-active Compounds.

Authors:  Jisun Kim; Chulwoo Park; James A Imlay; Woojun Park
Journal:  J Biol Chem       Date:  2016-11-28       Impact factor: 5.157

3.  Molecular cloning, characterization and localization of PfPK4, an eIF-2alpha kinase-related enzyme from the malarial parasite Plasmodium falciparum.

Authors:  J J Möhrle; Y Zhao; B Wernli; R M Franklin; B Kappes
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857

4.  The structure of the PERK kinase domain suggests the mechanism for its activation.

Authors:  Wenjun Cui; Jingzhi Li; David Ron; Bingdong Sha
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-04-13

Review 5.  Modulation of hepcidin as therapy for primary and secondary iron overload disorders: preclinical models and approaches.

Authors:  Paul J Schmidt; Mark D Fleming
Journal:  Hematol Oncol Clin North Am       Date:  2014-01-18       Impact factor: 3.722

6.  Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.

Authors:  Poulomi Acharya; Jane-Jane Chen; Maria Almira Correia
Journal:  Mol Pharmacol       Date:  2010-01-13       Impact factor: 4.436

7.  Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1.

Authors:  Hee Chul Lee; Thomas Hon; Changgui Lan; Li Zhang
Journal:  Mol Cell Biol       Date:  2003-08       Impact factor: 4.272

8.  The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates.

Authors:  Tapas Mukherjee; Valeria Ramaglia; Mena Abdel-Nour; Athanasia A Bianchi; Jessica Tsalikis; Hien N Chau; Suneil K Kalia; Lorraine V Kalia; Jane-Jane Chen; Damien Arnoult; Jennifer L Gommerman; Dana J Philpott; Stephen E Girardin
Journal:  J Biol Chem       Date:  2020-12-02       Impact factor: 5.157

9.  The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations.

Authors:  A Krupa; N Srinivasan
Journal:  Genome Biol       Date:  2002-11-13       Impact factor: 13.583

Review 10.  Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers.

Authors:  Manon Jaud; Céline Philippe; Doriana Di Bella; Weiwei Tang; Stéphane Pyronnet; Henrik Laurell; Laurent Mazzolini; Kevin Rouault-Pierre; Christian Touriol
Journal:  Cells       Date:  2020-02-26       Impact factor: 6.600
  10 in total

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