Synthesis and anticonvulsant activity of some new thiosemicarbazone and 4-thiazolidone derivatives bearing an isatin moiety.

A series of 3-thiosemicarbazono-2-indolinones and 3-(4-thiazolidone-2-hydrazono)-2-indolinones was synthesized by condensation of various isatin derivatives with 4-substituted 3-thiosemicarbazides and cyclization of the products by monochloroacetic acid or ethyl alpha-bromoacetate. In the present work we report on the structure determination and anticonvulsant evaluation of the title compounds.