Literature DB >> 7892608

Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.

D Lin1, T Sugawara, J F Strauss, B J Clark, D M Stocco, P Saenger, A Rogol, W L Miller.   

Abstract

Congenital lipoid adrenal hyperplasia is an autosomal recessive disorder that is characterized by impaired synthesis of all adrenal and gonadal steroid hormones. In three unrelated individuals with this disorder, steroidogenic acute regulatory protein, which enhances the mitochondrial conversion of cholesterol into pregnenolone, was mutated and nonfunctional, providing genetic evidence that this protein is indispensable normal adrenal and gonadal steroidogenesis.

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Year:  1995        PMID： 7892608     DOI： 10.1126/science.7892608

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  168 in total

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Authors:  H S Bose; R M Whittal; M A Baldwin; W L Miller
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Review 3.  Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

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Review 7.  Genetics of the adrenal gland.

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8.  Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia.

Authors:  K M Caron; S C Soo; W C Wetsel; D M Stocco; B J Clark; K L Parker
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 9.  Role of the steroidogenic acute regulatory protein in health and disease.

Authors:  Pulak R Manna; Cloyce L Stetson; Andrzej T Slominski; Kevin Pruitt
Journal:  Endocrine       Date:  2015-08-14       Impact factor: 3.633

10.  Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.

Authors:  Manjunath Ramanjaneya; Alex C Conner; Jing Chen; Peter R Stanfield; Harpal S Randeva
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736
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