Literature DB >> 7892504

The GRB family of SH2 domain proteins.

B Margolis1.   

Abstract

The cloning of SH2 domain proteins based on their binding to growth factor receptors is a powerful technique to elucidate new signaling pathways. In some cases the function of these proteins has been quickly ascertained while in others the answers still elude us. However the major power of the technique is its ability to identify novel signaling cascades that can emanate from tyrosine kinases. The challenge is to define the nature of these signaling cascades.

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Year:  1994        PMID： 7892504     DOI： 10.1016/0079-6107(94)90013-2

Source DB:  PubMed          Journal:  Prog Biophys Mol Biol        ISSN： 0079-6107            Impact factor:   3.667


  12 in total

1.  Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

Authors:  J Wang; H Dai; N Yousaf; M Moussaif; Y Deng; A Boufelliga; O R Swamy; M E Leone; H Riedel
Journal:  Mol Cell Biol       Date:  1999-09       Impact factor: 4.272

Review 2.  Binding of SH2 containing proteins to the insulin receptor: a new way for modulating insulin signalling.

Authors:  F Liu; R A Roth
Journal:  Mol Cell Biochem       Date:  1998-05       Impact factor: 3.396

Review 3.  Grb10 and Grb14: enigmatic regulators of insulin action--and more?

Authors:  Lowenna J Holt; Kenneth Siddle
Journal:  Biochem J       Date:  2005-06-01       Impact factor: 3.857

4.  Backbone nuclear relaxation characteristics and calorimetric investigation of the human Grb7-SH2/erbB2 peptide complex.

Authors:  Monika Ivancic; Anne M Spuches; Ethan C Guth; Margaret A Daugherty; Dean E Wilcox; Barbara A Lyons
Journal:  Protein Sci       Date:  2005-06       Impact factor: 6.725

5.  The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.

Authors:  L Laviola; F Giorgino; J C Chow; J A Baquero; H Hansen; J Ooi; J Zhu; H Riedel; R J Smith
Journal:  J Clin Invest       Date:  1997-03-01       Impact factor: 14.808

6.  Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.

Authors:  K Thömmes; J Lennartsson; M Carlberg; L Rönnstrand
Journal:  Biochem J       Date:  1999-07-01       Impact factor: 3.857

7.  Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2.

Authors:  Monika Ivancic; Roger J Daly; Barbara A Lyons
Journal:  J Biomol NMR       Date:  2003-11       Impact factor: 2.835

8.  The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta.

Authors:  Bertrand Cariou; Dominique Perdereau; Katia Cailliau; Edith Browaeys-Poly; Véronique Béréziat; Mireille Vasseur-Cognet; Jean Girard; Anne-Françoise Burnol
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

9.  Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules.

Authors:  De Pradip; Mark Bouzyk; Nandini Dey; Brian Leyland-Jones
Journal:  Am J Cancer Res       Date:  2013-04-03       Impact factor: 6.166

10.  Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity.

Authors:  Sheng Jiang; Chenzhong Liao; Lakshman Bindu; Biaolin Yin; Karen W Worthy; Robert J Fisher; Terrence R Burke; Marc C Nicklaus; Peter P Roller
Journal:  Bioorg Med Chem Lett       Date:  2009-03-29       Impact factor: 2.823
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