PURPOSE: To evaluate diagnostic accuracy with unenhanced and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) in cirrhotic livers. MATERIALS AND METHODS: Fifteen patients with 26 histologically proved HCCs associated with liver cirrhosis underwent imaging with T1-, T2-, and proton-density-weighted spin-echo (SE) and fast low-angle shot (FLASH) sequences. Lesion-to-liver contrast-to-noise ratios were measured in all sequences. Diagnostic performance of the imaging techniques was assessed by using receiver operating characteristic analysis. RESULTS: Enhanced SE and FLASH sequences were significantly more accurate (P < .005) for the detection of small HCCs. Among the unenhanced pulse sequences, the accuracy of tumor localization was highest with the T2-weighted SE sequences; however, 25% of the lesions were located incorrectly. Compared with unenhanced images, lesions were correctly located more often when SPIO-enhanced SE and FLASH sequences were used. CONCLUSION: SPIO-enhanced MR imaging with proton-density-weighted or FLASH sequences was more accurate in the detection of small HCCs in cirrhotic livers.
PURPOSE: To evaluate diagnostic accuracy with unenhanced and superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging for detection of hepatocellular carcinoma (HCC) in cirrhotic livers. MATERIALS AND METHODS: Fifteen patients with 26 histologically proved HCCs associated with liver cirrhosis underwent imaging with T1-, T2-, and proton-density-weighted spin-echo (SE) and fast low-angle shot (FLASH) sequences. Lesion-to-liver contrast-to-noise ratios were measured in all sequences. Diagnostic performance of the imaging techniques was assessed by using receiver operating characteristic analysis. RESULTS: Enhanced SE and FLASH sequences were significantly more accurate (P < .005) for the detection of small HCCs. Among the unenhanced pulse sequences, the accuracy of tumor localization was highest with the T2-weighted SE sequences; however, 25% of the lesions were located incorrectly. Compared with unenhanced images, lesions were correctly located more often when SPIO-enhanced SE and FLASH sequences were used. CONCLUSION:SPIO-enhanced MR imaging with proton-density-weighted or FLASH sequences was more accurate in the detection of small HCCs in cirrhotic livers.
Authors: Janine Rennert; Ernst-Michael Jung; Andreas G Schreyer; Patrick Hoffstetter; Peter Heiss; Stefan Feuerbach; Niels Zorger Journal: World J Gastroenterol Date: 2011-04-07 Impact factor: 5.742
Authors: G Simon; T M Link; K Wörtler; F Doebereiner; E Schulte-Frohlinde; H Daldrup-Link; M Settles; E J Rummeny Journal: Eur Radiol Date: 2005-03-31 Impact factor: 5.315
Authors: Se Hyung Kim; Jeong Min Lee; Joon Koo Han; Jae Young Lee; Won Joon Kang; Jin Young Jang; Kyung-Sook Shin; Kyunghee C Cho; Byung Ihn Choi Journal: Eur Radiol Date: 2006-03-18 Impact factor: 5.315