Literature DB >> 7892294

Estrogenic flavonoids: structural requirements for biological activity.

R J Miksicek1.   

Abstract

A systematic survey of polycyclic phenols has been performed to identify members of this chemical group with estrogenic activity. Twelve compounds were found to be able to stimulate the transcriptional activity of the human estrogen receptor expressed in cultured cells by transient transfection. These natural estrogens belong to several distinct, but chemically related classes including chalcones, flavanones, flavones, flavonols, and isoflavones. Selected examples of estrogenic flavonoids were further analyzed to determine their biological potencies and their relative affinities for binding to the estrogen receptor. These data are interpreted with respect to the molecular structure of polycyclic phenols required for hormonal activity as nonsteroidal estrogens.

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Year:  1995        PMID： 7892294     DOI： 10.3181/00379727-208-43830

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN： 0037-9727


  31 in total

1.  trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets.

Authors:  Y Dobrydneva; R L Williams; P F Blackmore
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

2.  Ovariectomy alters energy metabolism in rat striatum: effect of supplementation with soy diet rich in isoflavones.

Authors:  Vanize Mackedanz; Cristiane B Mattos; Luciane R Feksa; Clovis M D Wannmacher; Angela T S Wyse
Journal:  Metab Brain Dis       Date:  2010-11-12       Impact factor: 3.584

3.  Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae.

Authors:  Effendi Leonard; Yajun Yan; Kok Hong Lim; Mattheos A G Koffas
Journal:  Appl Environ Microbiol       Date:  2005-12       Impact factor: 4.792

4.  Is there an estrogenic component in the metabolic syndrome?

Authors:  S Starcke; G Vollmer
Journal:  Genes Nutr       Date:  2006-09       Impact factor: 5.523

5.  Association between dietary intake of flavonoid and bone mineral density in middle aged and elderly Chinese women and men.

Authors:  Z-Q Zhang; L-P He; Y-H Liu; J Liu; Y-X Su; Y-M Chen
Journal:  Osteoporos Int       Date:  2014-07-26       Impact factor: 4.507

6.  Use of alpha-, beta-Estrogen Receptor as a "new tool" for detection of specific small molecule activity.

Authors:  Samir Kumar Gunjan; Dennis Trent Rogers; Jingxian Zhang; Kil-Young Yun; Deane L Falcone; John Littleton
Journal:  Plant Mol Biol Report       Date:  2015-03-26       Impact factor: 1.595

Review 7.  Risks and benefits of soy phytoestrogens in cardiovascular diseases, cancer, climacteric symptoms and osteoporosis.

Authors:  C R Sirtori
Journal:  Drug Saf       Date:  2001       Impact factor: 5.606

8.  Estrogen-like neuroprotection of isopsoralen against spinal cord injury through estrogen receptor ERα.

Authors:  Xiao-Ming Li; Qi Yang; Xu-Bo Li; Qiang Cheng; Kun Zhang; Jing Han; Jian-Ning Zhao; Gang Liu; Ming-Gao Zhao
Journal:  Metab Brain Dis       Date:  2016-09-26       Impact factor: 3.584

Review 9.  Phytoestrogens, body composition, and breast cancer.

Authors:  P L Horn-Ross
Journal:  Cancer Causes Control       Date:  1995-11       Impact factor: 2.506

10.  Evaluation of synthetic isoflavones on cell proliferation, estrogen receptor binding affinity, and apoptosis in human breast cancer cells.

Authors:  Danyetta D Davis; Edgar S Díaz-Cruz; Serena Landini; Young-Woo Kim; Robert W Brueggemeier
Journal:  J Steroid Biochem Mol Biol       Date:  2007-09-07       Impact factor: 4.292
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