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Literature DB >> 7892281

Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells.

G Risdon¹, J Gaddy, M Horie, H E Broxmeyer.

Abstract

Induction of alloreactivity in human adult and umbilical cord blood T cells was evaluated in mixed leukocyte culture by exposure to an allogeneic lymphoblastoid line that expresses known costimulatory molecules. Initial exposure to alloantigen-presenting cells (allo-APC) induced strong proliferative responses in both adult and cord blood T cells. However, in contrast to adult T cells, cord blood T cells exhibited little proliferation after restimulation with donor APC. Primed cord blood T cells could respond to interleukin 2 (IL-2), but unresponsiveness to alloantigen was not overcome by addition of exogenous IL-2. Unresponsiveness was long-lasting and appeared to be maintained by a combination of induction of anergy and activity of CD8+ suppressor cells. This information may contribute to use of human cord blood as an allogeneic source of transplantable stem cells.

Entities: Gene Species

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Year: 1995 PMID： 7892281 PMCID： PMC42494 DOI： 10.1073/pnas.92.6.2413

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

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3. CD40-deficient dendritic cells producing interleukin-10, but not interleukin-12, induce T-cell hyporesponsiveness in vitro and prevent acute allograft rejection.

Authors: J X Gao; J Madrenas; W Zeng; M J Cameron; Z Zhang; J J Wang; R Zhong; D Grant
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