R C Eagle1, R A Penne, I S Hneleski. 1. Department of Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107.
Abstract
CASE REPORT: The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had produced a characteristic telescoping deformity of the digits. Eyelid nodules were excised to relieve pseudoptosis and for cosmesis. MATERIALS: The eyelid nodules were studied by routine light microscopy and a battery of immunohistochemical stains, including S-100 protein and several macrophage markers. RESULTS: Microscopy disclosed an infiltrate of histiocytes and giant cells with glassy eosinophilic cytoplasm and large round or oval vesicular nuclei with prominent nucleoli set in a densely fibrotic stroma consistent with multicentric reticulohistiocytosis. The histiocytes showed positive immunoreactivity for lysozyme, but were negative for alpha-1 antichymotrypsin, S-100 protein, and neuron-specific enolase. CONCLUSION: Multicentric reticulohistiocytosis should be included in the differential diagnosis of multiple eyelid nodules.
CASE REPORT: The authors report the first biopsy-confirmed ocular adnexal involvement by multicentric reticulohistiocytosis. The patient was a 28-year-old black woman with a 15-year history of well-documented multicentric reticulohistiocytosis who had multiple dermal nodules and severe mutilating arthritis that had produced a characteristic telescoping deformity of the digits. Eyelid nodules were excised to relieve pseudoptosis and for cosmesis. MATERIALS: The eyelid nodules were studied by routine light microscopy and a battery of immunohistochemical stains, including S-100 protein and several macrophage markers. RESULTS: Microscopy disclosed an infiltrate of histiocytes and giant cells with glassy eosinophilic cytoplasm and large round or oval vesicular nuclei with prominent nucleoli set in a densely fibrotic stroma consistent with multicentric reticulohistiocytosis. The histiocytes showed positive immunoreactivity for lysozyme, but were negative for alpha-1 antichymotrypsin, S-100 protein, and neuron-specific enolase. CONCLUSION: Multicentric reticulohistiocytosis should be included in the differential diagnosis of multiple eyelid nodules.
Authors: Arshia D Islam; Stanley M Naguwa; Gurtej S Cheema; John C Hunter; M Eric Gershwin Journal: Clin Rev Allergy Immunol Date: 2013-10 Impact factor: 8.667