Literature DB >> 7891897

Iron, selenium and glutathione peroxidase activity are elevated in sporadic motor neuron disease.

P G Ince1, P J Shaw, J M Candy, D Mantle, L Tandon, W D Ehmann, W R Markesbery.   

Abstract

Oxygen free radical damage is strongly implicated in the pathogenesis of familial motor neuron disease (MND) associated with mutation of the Cu/Zn superoxide dismutase gene, and may be relevant in sporadic MND. Selenium (Se) and iron (Fe) have important roles in free radical metabolism. Using neutron activation analysis we have demonstrated significant elevation of Se and Fe in lumbar spinal cord in MND cases (38) compared to controls (22). Analysis of enzymes involved in free radical scavenging showed a significant and specific increase in the activity of the selenoprotein enzyme glutathione peroxidase in MND spinal cord.

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Year:  1994        PMID： 7891897     DOI： 10.1016/0304-3940(94)90213-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  23 in total

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Authors:  D Liu
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

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Journal:  Neurochem Res       Date:  2006-05-03       Impact factor: 3.996

3.  Serum ferritin is a candidate biomarker of disease aggravation in amyotrophic lateral sclerosis.

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Journal:  Biomed Rep       Date:  2018-08-02

Review 4.  Glutamate, excitotoxicity and amyotrophic lateral sclerosis.

Authors:  P J Shaw; P G Ince
Journal:  J Neurol       Date:  1997-05       Impact factor: 4.849

5.  A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice.

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Journal:  Neurotox Res       Date:  2016-11-08       Impact factor: 3.911

Review 6.  Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications.

Authors:  D Allan Butterfield; Marzia Perluigi; Tanea Reed; Tasneem Muharib; Christopher P Hughes; Renã A S Robinson; Rukhsana Sultana
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7.  Beneficial Effects of Multitarget Iron Chelator on Central Nervous System and Gastrocnemius Muscle in SOD1(G93A) Transgenic ALS Mice.

Authors:  Sagit Golko-Perez; Tamar Amit; Moussa B H Youdim; Orly Weinreb
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8.  Increased serum ferritin levels in amyotrophic lateral sclerosis (ALS) patients.

Authors:  E F Goodall; M S Haque; K E Morrison
Journal:  J Neurol       Date:  2008-07-18       Impact factor: 4.849

9.  Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.

Authors:  Marco Vinceti; Nikolay Solovyev; Jessica Mandrioli; Catherine M Crespi; Francesca Bonvicini; Elisa Arcolin; Eleni Georgoulopoulou; Bernhard Michalke
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10.  Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis.

Authors:  Sagit Golko-Perez; Silvia Mandel; Tamar Amit; Lana Kupershmidt; Moussa B H Youdim; Orly Weinreb
Journal:  Neurotox Res       Date:  2015-11-18       Impact factor: 3.911
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