Literature DB >> 7891078

Localization of basic fibroblast growth factor in bovine adrenal chromaffin cells.

S C Bieger1, A W Henkel, K Unsicker.   

Abstract

We have investigated basic fibroblast growth factor (FGF-2) localization in and release from isolated bovine adrenal chromaffin cells. In contrast to previous reports, we found no evidence of fibroblast growth factor (FGF) storage in catecholamine-containing chromaffin granules. Subcellular fractionation studies did not show enrichment of FGF-2 immunoreactivity in granules, and cholinergic stimulation failed to release FGF-2 into the medium. Our results suggest that adrenal chromaffin cells resemble other FGF-2-synthesizing cell types with respect to FGF storage and secretion.

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Year:  1995        PMID： 7891078     DOI： 10.1046/j.1471-4159.1995.64041521.x

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  4 in total

1.  TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla.

Authors:  A Schober; N Wolf; K Huber; R Hertel; K Krieglstein; L Minichiello; N Kahane; J Widenfalk; C Kalcheim; L Olson; R Klein; G R Lewin; K Unsicker
Journal:  J Neurosci       Date:  1998-09-15       Impact factor: 6.167

2.  Stimulation of neonatal and adult brain neurogenesis by subcutaneous injection of basic fibroblast growth factor.

Authors:  J P Wagner; I B Black; E DiCicco-Bloom
Journal:  J Neurosci       Date:  1999-07-15       Impact factor: 6.167

Review 3.  Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism.

Authors:  M K Stachowiak; J Moffett; P Maher; J Tucholski; E K Stachowiak
Journal:  Mol Neurobiol       Date:  1997-12       Impact factor: 5.590

4.  Glial cell line-derived neurotrophic factor requires transforming growth factor-beta for exerting its full neurotrophic potential on peripheral and CNS neurons.

Authors:  K Krieglstein; P Henheik; L Farkas; J Jaszai; D Galter; K Krohn; K Unsicker
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167
  4 in total

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