Literature DB >> 7889508

Monosomy 1p is correlated with enhanced in vivo glucose metabolism in meningiomas.

W Henn1, U Cremerius, G Heide, B Lippitz, J M Schröder, J M Gilsbach, U Büll, K D Zang.   

Abstract

The 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake of 25 human meningiomas was preoperatively evaluated in vivo by positron-emission tomography (PET). After surgery, meningioma biopsies were analyzed cytogenetically. Five meningiomas showed partial monosomy for chromosome 1p additional to other typical chromosome aberrations. This aberrant karyotype was correlated with increased FDG uptake. Three of five meningiomas with monosomy 1p were classified as grade II according to WHO, while only one of 20 tumors without monosomy 1p was classified as grade II. Thus, monosomy 1p and elevated FDG uptake in PET are to be regarded as cytogenetic and metabolic parameters for the aggressiveness of meningiomas.

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Year:  1995        PMID： 7889508     DOI： 10.1016/0165-4608(94)00135-x

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  5 in total

1.  Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.

Authors:  René G Feichtinger; Serge Weis; Johannes A Mayr; Franz A Zimmermann; Barbara Bogner; Wolfgang Sperl; Barbara Kofler
Journal:  Neuro Oncol       Date:  2015-06-23       Impact factor: 12.300

2.  Triple approach for diagnosis and grading of meningiomas: histology, morphometry of Ki-67/Feulgen stainings, and cytogenetics.

Authors:  H Kolles; I Niedermayer; C Schmitt; W Henn; R Feld; W I Steudel; K D Zang; W Feiden
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

Review 3.  Prediction of Meningioma WHO Grade Using PET Findings: A Systematic Review and Meta-Analysis.

Authors:  K Mariam Slot; Dagmar Verbaan; Dennis R Buis; Linda J Schoonmade; Bart N M Berckel; W Peter Vandertop
Journal:  J Neuroimaging       Date:  2020-11-02       Impact factor: 2.486

4.  Establishment of a molecular cytogenetic analysis for native tumor tissue of meningiomas-suitable for clinical application.

Authors:  Cornelia Lerner; Ralf Ketter; Stefan Linsler; Wolfram Henn; Joachim Oertel; Steffi Urbschat
Journal:  Mol Cytogenet       Date:  2014-02-05       Impact factor: 2.009

5.  Molecular biological determinations of meningioma progression and recurrence.

Authors:  Stefan Linsler; Dennis Kraemer; Christina Driess; Joachim Oertel; Kai Kammers; Jörg Rahnenführer; Ralf Ketter; Steffi Urbschat
Journal:  PLoS One       Date:  2014-04-10       Impact factor: 3.240
  5 in total

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