Literature DB >> 7889324

Acyclovir-resistant, pathogenic herpesviruses.

D M Coen1.   

Abstract

In herpes simplex virus, the simplest path to resistance to the drug acyclovir is a mutation that knocks out the enzyme thymidine kinase. Such mutants are highly attenuated in mouse models of viral pathogenesis, but have been reported to be associated with severe disease in immunocompromised patients. This review discusses possible resolution of this paradox.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7889324     DOI： 10.1016/0966-842x(94)90652-1

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  20 in total

Review 1.  Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Authors:  Jocelyne Piret; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin.

Authors:  Graciela Andrei; Jan Balzarini; Pierre Fiten; Erik De Clercq; Ghislain Opdenakker; Robert Snoeck
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

3.  A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits.

Authors:  Partha S Bhattacharjee; Donna M Neumann; James M Hill
Journal:  Curr Eye Res       Date:  2009-02       Impact factor: 2.424

4.  Diagnosis and treatment of cutaneous herpes simplex virus infections.

Authors:  C Cockerell
Journal:  West J Med       Date:  1996-06

5.  Phosphorylation of a herpes simplex virus 1 dUTPase by a viral protein kinase, Us3, dictates viral pathogenicity in the central nervous system but not at the periphery.

Authors:  Akihisa Kato; Keiko Shindo; Yuhei Maruzuru; Yasushi Kawaguchi
Journal:  J Virol       Date:  2013-12-18       Impact factor: 5.103

6.  Novel class of thiourea compounds that inhibit herpes simplex virus type 1 DNA cleavage and encapsidation: resistance maps to the UL6 gene.

Authors:  M van Zeijl; J Fairhurst; T R Jones; S K Vernon; J Morin; J LaRocque; B Feld; B O'Hara; J D Bloom; S V Johann
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

Review 7.  Antiviral drug resistance: mechanisms and clinical implications.

Authors:  Lynne Strasfeld; Sunwen Chou
Journal:  Infect Dis Clin North Am       Date:  2010-06       Impact factor: 5.982

8.  Comparative evaluation of colorimetric microtiter plate systems for detection of herpes simplex virus in cerebrospinal fluid.

Authors:  Y W Tang; P N Rys; B J Rutledge; P S Mitchell; T F Smith; D H Persing
Journal:  J Clin Microbiol       Date:  1998-09       Impact factor: 5.948

9.  Longitudinal Characterization of Herpes Simplex Virus (HSV) Isolates Acquired From Different Sites in an Immune-Compromised Child: A New HSV Thymidine Kinase Mutation Associated With Resistance.

Authors:  Andrew H Karaba; Laura K Cohen; Taly Glaubach; Sarah J Kopp; Jennifer L Reichek; Hawke H Yoon; Xiaotian T Zheng; William J Muller
Journal:  J Pediatric Infect Dis Soc       Date:  2012-05-03       Impact factor: 3.164

10.  Inhibition of herpes simplex virus replication by a 2-amino thiazole via interactions with the helicase component of the UL5-UL8-UL52 complex.

Authors:  F C Spector; L Liang; H Giordano; M Sivaraja; M G Peterson
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.