Literature DB >> 7888103

Altered GABAergic and glutamatergic transmission in audiogenic seizure-susceptible mice.

M L Cordero1, J G Ortiz, G Santiago, A Negrón, J A Moreira.   

Abstract

The C57BL/10 SPS/sps mouse mutant are audiogenic seizure-susceptible. The enzymatic activities of glutamate decarboxylase (GAD), GABA aminotransferase (GABA-T), alanine aminotransferase (ALA-T), aspartate aminotransferase (ASP-T), and glutamate dehydrogenase (GDH) of whole brain supernatant are significantly reduced in these epileptic mice. GABA uptake is decreased in cortex, midbrain, and pons medulla. Previous studies showed the presence of two sodium-dependent GLU uptake systems in normal (SPS/SP) mice. Glutamate Umax by System 1 is significantly decreased in these mice, whereas the Umax value for System 2 is significantly increased in the epileptic mice.

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Year:  1994        PMID： 7888103     DOI： 10.1007/BF02816124

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  15 in total

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Authors:  M B Robinson; M Hunter-Ensor; J Sinor
Journal:  Brain Res       Date:  1991-03-29       Impact factor: 3.252

Review 2.  Transporter explosion: update on uptake.

Authors:  G R Uhl; P R Hartig
Journal:  Trends Pharmacol Sci       Date:  1992-12       Impact factor: 14.819

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Journal:  Brain Res       Date:  1977-02-11       Impact factor: 3.252

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Journal:  Brain Res       Date:  1972-05-26       Impact factor: 3.252

5.  Enhanced aspartate release from hippocampal slices of epileptic (El) mice.

Authors:  H J Flavin; A Wieraszko; T N Seyfried
Journal:  J Neurochem       Date:  1991-03       Impact factor: 5.372

6.  A mutant for spontaneous seizures in C57BL/10Bg mice.

Authors:  S C Maxson; M D Fine; B E Ginsburg; D L Koniecki
Journal:  Epilepsia       Date:  1983-02       Impact factor: 5.864

7.  GABAergic neurotransmission in the C57BL/10 sps/sps mouse mutant: a model of absence seizures.

Authors:  J G Ortiz; A E Negrón; A P Thomas; H Heimer; J A Moreira; M L Cordero; J Aranda; M S Bruno
Journal:  Exp Neurol       Date:  1991-09       Impact factor: 5.330

8.  Primary structure and functional characterization of a high-affinity glutamate transporter.

Authors:  Y Kanai; M A Hediger
Journal:  Nature       Date:  1992-12-03       Impact factor: 49.962

9.  High affinity [3H]glutamate uptake systems in normal and audiogenic seizure-susceptible mice.

Authors:  M L Cordero; J G Ortiz; G Santiago
Journal:  Brain Res Dev Brain Res       Date:  1994-03-18

10.  Cloning and expression of a rat brain L-glutamate transporter.

Authors:  G Pines; N C Danbolt; M Bjørås; Y Zhang; A Bendahan; L Eide; H Koepsell; J Storm-Mathisen; E Seeberg; B I Kanner
Journal:  Nature       Date:  1992-12-03       Impact factor: 49.962
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  2 in total

1.  Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties.

Authors:  P Bac; P Maurois; C Dupont; N Pages; J P Stables; P Gressens; P Evrard; J Vamecq
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

2.  Effects of Valeriana officinalis extracts on [3H]flunitrazepam binding, synaptosomal [3H]GABA uptake, and hippocampal [3H]GABA release.

Authors:  J G Ortiz; J Nieves-Natal; P Chavez
Journal:  Neurochem Res       Date:  1999-11       Impact factor: 3.996
  2 in total

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