Literature DB >> 788731

Effect of indomethacin in asthma: evidence against a role for prostaglandins in its pathogenesis.

A P Smith.   

Abstract

1. A clinical trial of the effects of indomethacin (200 mg daily) failed to show any objective evidence of improvement in six patients. 2. The same dose failed to inhibit exercise and antigen challenge induced bronchoconstriction, and this was considered to be evidence against the hypothesis that prostaglandins act as chemical mediatros in the pathogenesis of asthma.

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Year:  1975        PMID： 788731      PMCID： PMC1402590          DOI： 10.1111/j.1365-2125.1975.tb02775.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  9 in total

1.  Distribution of prostaglandins in human tissues.

Authors:  S M Karim; M Sandler; E D Williams
Journal:  Br J Pharmacol Chemother       Date:  1967

2.  Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors:  P J Piper; J R Vane
Journal:  Nature       Date:  1969-07-05       Impact factor: 49.962

3.  Effects of prostaglandins on human bronchial muscle.

Authors:  W J Sweatman; H O Collier
Journal:  Nature       Date:  1968-01-06       Impact factor: 49.962

4.  Prostaglandin regulation of airway smooth muscle tone.

Authors:  J Orehek; J S Douglas; A J Lewis; A Bouhuys
Journal:  Nat New Biol       Date:  1973-09-19

5.  Icreased excretion of 5alpha, 7alpha-dihydroxy-11-keto-tetranor-prostanoic acid on anaphylaxis in the guinea-pig.

Authors:  K Strandberg; M Hamberg
Journal:  Prostaglandins       Date:  1974-04-25

6.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors:  J R Vane
Journal:  Nat New Biol       Date:  1971-06-23

7.  Increased plasma levels of 15-keto-13,14-dihydro-prostaglandin F2X after allergen-provoked asthma in man.

Authors:  K Gréen; P Hedqvist; N Svanborg
Journal:  Lancet       Date:  1974-12-14       Impact factor: 79.321

8.  Antagonistic Action of Aerosols of Prostaglandins F(2)alpha and E(2) on Bronchial Muscle Tone in Man.

Authors:  A P Smith; M F Cuthbert
Journal:  Br Med J       Date:  1972-07-22

9.  The release of spasmogenic substances from human chopped lung tissue and its inhibition.

Authors:  P J Piper; J L Walker
Journal:  Br J Pharmacol       Date:  1973-02       Impact factor: 8.739
  9 in total
  5 in total

1.  Prostaglandins and asthma.

Authors:  M F Cuthbert
Journal:  Br J Clin Pharmacol       Date:  1975-08       Impact factor: 4.335

2.  The mechanism of action of leukotrienes A4, C4 and D4 on human lung parenchyma in vitro.

Authors:  M Chagnon; J Gentile; M Gladu; P Sirois
Journal:  Lung       Date:  1985       Impact factor: 2.584

3.  Effects of inhibitors of anaphylactic mediators in two models of bronchial anaphylaxis in anaesthetized guinea-pigs.

Authors:  P Andersson
Journal:  Br J Pharmacol       Date:  1982-10       Impact factor: 8.739

4.  The late reaction following bronchial provocation with house dust mite allergen. Dependence on arachidonic acid metabolism.

Authors:  A J Fairfax; J M Hanson; J Morley
Journal:  Clin Exp Immunol       Date:  1983-05       Impact factor: 4.330

5.  Effects of a cyclo-oxygenase inhibitor, flurbiprofen, and an H1 histamine receptor antagonist, terfenadine, alone and in combination on allergen induced immediate bronchoconstriction in man.

Authors:  N Curzen; P Rafferty; S T Holgate
Journal:  Thorax       Date:  1987-12       Impact factor: 9.139
  5 in total

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