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Literature DB >> 7884926

Encephalomyocarditis viruses with short poly(C) tracts are more virulent than their mengovirus counterparts.

Abstract

We have constructed three cDNA clones of encephalomyocarditis virus strain R (EMCV-R) with poly(C) tracts of C4, C9, and C20. RNA transcribed from these cDNAs was infectious to HeLa cells, and the resultant viruses grew well in this system, albeit with plaque sizes that were proportional to the poly(C) length. When injected into mice, the progeny viruses were only slightly less pathogenic than EMCV-R, and the observed degree of attenuation was not nearly as dramatic as for equivalent mengoviruses with similar short poly(C)s. Short-tract poly(C)-mediated attenuation is therefore highly dependent on viral genomic context.

Entities: Chemical Disease Species

Mesh：

Substances：
DNA, Complementary
Poly C

Year: 1995 PMID： 7884926 PMCID： PMC188958

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

10 in total

1. Sequence and location of the poly C tract in aphtho- and cardiovirus RNA.

Authors: D N Black; P Stephenson; D J Rowlands; F Brown
Journal: Nucleic Acids Res Date: 1979-06-11 Impact factor: 16.971

2. Construction and characterization of two infectious molecular clones of encephalomyocarditis virus.

Authors: R K Naviaux; S H Cohen; K M Vanden Brink; G W Jordan
Journal: J Virol Date: 1990-02 Impact factor: 5.103

3. Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences.

Authors: H Land; M Grez; H Hauser; W Lindenmaier; G Schütz
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

4. Transformation of E. coli using homopolymer-linked plasmid chimeras.

Authors: S L Peacock; C M McIver; J J Monahan
Journal: Biochim Biophys Acta Date: 1981-09-28

5. Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts.

Authors: G M Duke; A C Palmenberg
Journal: J Virol Date: 1989-04 Impact factor: 5.103

6. Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA.

Authors: A Zibert; G Maass; K Strebel; M M Falk; E Beck
Journal: J Virol Date: 1990-06 Impact factor: 5.103

7. Attenuation of Mengo virus through genetic engineering of the 5' noncoding poly(C) tract.

Authors: G M Duke; J E Osorio; A C Palmenberg
Journal: Nature Date: 1990-02-01 Impact factor: 49.962

Review 8. Cardioviral poly(C) tracts and viral pathogenesis.

Authors: A C Palmenberg; J E Osorio
Journal: Arch Virol Suppl Date: 1994

9. Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice.

Authors: E Rieder; T Bunch; F Brown; P W Mason
Journal: J Virol Date: 1993-09 Impact factor: 5.103

10. Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation.

Authors: G M Duke; M A Hoffman; A C Palmenberg
Journal: J Virol Date: 1992-03 Impact factor: 5.103

10 in total

36 in total

1. Phenotypic characterization of three phylogenetically conserved stem-loop motifs in the mengovirus 3' untranslated region.

Authors: H Duque; A C Palmenberg
Journal: J Virol Date: 2001-04 Impact factor: 5.103

10. Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner.

Authors: Matthew S Walters; Christos A Kyratsous; Shilin Wan; Saul Silverstein
Journal: J Virol Date: 2008-06-18 Impact factor: 5.103

Encephalomyocarditis viruses with short poly(C) tracts are more virulent than their mengovirus counterparts.

1. Sequence and location of the poly C tract in aphtho- and cardiovirus RNA.

2. Construction and characterization of two infectious molecular clones of encephalomyocarditis virus.

3. Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences.

4. Transformation of E. coli using homopolymer-linked plasmid chimeras.

5. Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts.

6. Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA.

7. Attenuation of Mengo virus through genetic engineering of the 5' noncoding poly(C) tract.

Review 8. Cardioviral poly(C) tracts and viral pathogenesis.

9. Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice.

10. Sequence and structural elements that contribute to efficient encephalomyocarditis virus RNA translation.

1. Phenotypic characterization of three phylogenetically conserved stem-loop motifs in the mengovirus 3' untranslated region.

2. Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture.

3. A picornavirus protein interacts with Ran-GTPase and disrupts nucleocytoplasmic transport.

4. Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.

5. Mutational analysis of the encephalomyocarditis virus primary cleavage.

6. Cleavage site mutations in the encephalomyocarditis virus P3 region lethally abrogate the normal processing cascade.

7. Tandem mengovirus 5' pseudoknots are linked to viral RNA synthesis, not poly(C)-mediated virulence.

8. Mutational analysis of the mengovirus poly(C) tract and surrounding heteropolymeric sequences.

9. Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardioviruses.

10. Nuclear import of the varicella-zoster virus latency-associated protein ORF63 in primary neurons requires expression of the lytic protein ORF61 and occurs in a proteasome-dependent manner.