Literature DB >> 7884484

TTX-resistant NMDA receptor-mediated voltage oscillations in mammalian lumbar motoneurons.

S Hochman1, L M Jordan, B J Schmidt.   

Abstract

1. Whole cell current-clamp recordings were obtained from tetrodotoxin (TTX)-isolated motoneurons in the in vitro neonatal rat spinal cord to examine the effects of N-methyl-D-aspartate (NMDA) receptor activation on membrane voltage. 2. NMDA induced rhythmic membrane voltage oscillations, and injection of current ramps revealed the presence of bistable membrane properties, the base and peak of which corresponded to the base and peak values of the voltage oscillations. 3. Nonlinear motoneuron membrane properties induced by NMDA receptor activation may be well suited to reinforce rhythmic patterns of motor output during certain behaviors such as locomotion.

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Year:  1994        PMID： 7884484     DOI： 10.1152/jn.1994.72.5.2559

Source DB:  PubMed          Journal:  J Neurophysiol        ISSN： 0022-3077            Impact factor:   2.714


  21 in total

1.  Shining light into the black box of spinal locomotor networks.

Authors:  Patrick J Whelan
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2010-08-12       Impact factor: 6.237

2.  Two distinct oscillatory states determined by the NMDA receptor in rat inferior olive.

Authors:  D Placantonakis; J Welsh
Journal:  J Physiol       Date:  2001-07-01       Impact factor: 5.182

Review 3.  Synaptic control of motoneuronal excitability.

Authors:  J C Rekling; G D Funk; D A Bayliss; X W Dong; J L Feldman
Journal:  Physiol Rev       Date:  2000-04       Impact factor: 37.312

4.  Initiation of segmental locomotor-like activities by stimulation of ventrolateral funiculus in the neonatal rat.

Authors:  Jianguo Cheng; David S K Magnuson
Journal:  Exp Brain Res       Date:  2011-08-21       Impact factor: 1.972

5.  Motoneuron activity patterns related to the earliest behavior of the zebrafish embryo.

Authors:  L Saint-Amant; P Drapeau
Journal:  J Neurosci       Date:  2000-06-01       Impact factor: 6.167

6.  Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis.

Authors:  Mingchen Jiang; Jenna E Schuster; Ronggen Fu; Teepu Siddique; C J Heckman
Journal:  J Neurosci       Date:  2009-12-02       Impact factor: 6.167

7.  Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network.

Authors:  Frédéric Brocard; Natalia A Shevtsova; Mouloud Bouhadfane; Sabrina Tazerart; Uwe Heinemann; Ilya A Rybak; Laurent Vinay
Journal:  Neuron       Date:  2013-03-20       Impact factor: 17.173

Review 8.  Motoneuron excitability: the importance of neuromodulatory inputs.

Authors:  C J Heckman; Carol Mottram; Kathy Quinlan; Renee Theiss; Jenna Schuster
Journal:  Clin Neurophysiol       Date:  2009-09-27       Impact factor: 3.708

9.  Electrophysiological and pharmacological properties of locomotor activity-related neurons in cfos-EGFP mice.

Authors:  Yue Dai; Kevin P Carlin; Zongming Li; Douglas G McMahon; Robert M Brownstone; Larry M Jordan
Journal:  J Neurophysiol       Date:  2009-09-30       Impact factor: 2.714

10.  Control of locomotion in the marine mollusc Clione limacina. XI. Effects of serotonin.

Authors:  Y V Panchin; Y I Arshavsky; T G Deliagina; G N Orlovsky; L B Popova; A I Selverston
Journal:  Exp Brain Res       Date:  1996-05       Impact factor: 1.972
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