Literature DB >> 7883775

Possible lack of full cross-resistance of 5HT3 antagonists; a pilot study.

M de Boer1, R de Wit, G Stoter, J Verweij.   

Abstract

We investigated the potential of cross-over to the serotonin receptor (5HT3) antagonist ondansetron after protection failure with tropisetron. Several cases of complete protection were observed. These limited data suggest that there is an indication for retreatment with a different 5HT3 antagonist after an initial failure to another and also stress the need and relevance for comparative studies between 5HT3 antagonists.

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Year:  1995        PMID： 7883775     DOI： 10.1007/bf01202225

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  4 in total

Review 1.  5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron.

Authors:  C Seynaeve; J Verweij; P H de Mulder
Journal:  Anticancer Drugs       Date:  1991-08       Impact factor: 2.248

2.  Comparison of the 5-hydroxytryptamine3 (serotonin) antagonist ondansetron (GR 38032F) with high-dose metoclopramide in the control of cisplatin-induced emesis.

Authors:  M Marty; P Pouillart; S Scholl; J P Droz; M Azab; N Brion; E Pujade-Lauraine; B Paule; D Paes; J Bons
Journal:  N Engl J Med       Date:  1990-03-22       Impact factor: 91.245

3.  Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. A multicenter, randomized, double-blind, crossover study.

Authors:  P H De Mulder; C Seynaeve; J B Vermorken; P A van Liessum; S Mols-Jevdevic; E L Allman; P Beranek; J Verweij
Journal:  Ann Intern Med       Date:  1990-12-01       Impact factor: 25.391

4.  Difference in persistence of efficacy of two antiemetic regimens on acute emesis during cisplatin chemotherapy. The Italian Group for Antiemetic Research.

Authors: 
Journal:  J Clin Oncol       Date:  1993-12       Impact factor: 44.544
  4 in total
  1 in total

1.  Effective cross-over to granisetron after failure to ondansetron, a randomized double blind study in patients failing ondansetron plus dexamethasone during the first 24 hours following highly emetogenic chemotherapy.

Authors:  R de Wit; A C de Boer; G H vd Linden; G Stoter; A Sparreboom; J Verweij
Journal:  Br J Cancer       Date:  2001-10-19       Impact factor: 7.640
  1 in total

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