Literature DB >> 7883743

Selective hydrolysis of tRNA by ethylenediamine bound to a DNA oligomer.

M Komiyama1, T Inokawa.   

Abstract

A sequence-selective artificial ribonuclease was prepared by attaching ethylenediamine to the 5'-end of a DNA oligomer as the sequence-recognizing moiety. The hybrid, incorporating a 19-mer DNA which is complementary with the A44-A62 sequence of tRNA(Phe), hydrolyzed the tRNA selectively at the 3'-side of C63.

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Year:  1994        PMID： 7883743     DOI： 10.1093/oxfordjournals.jbchem.a124586

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  5 in total

1.  Sequence-specific artificial ribonucleases. I. Bis-imidazole-containing oligonucleotide conjugates prepared using precursor-based strategy.

Authors:  Natalia G Beloglazova; Martin M Fabani; Marina A Zenkova; Elena V Bichenkova; Nikolai N Polushin; Vladimir V Sil'nikov; Kenneth T Douglas; Valentin V Vlassov
Journal:  Nucleic Acids Res       Date:  2004-07-23       Impact factor: 16.971

2.  Antisense oligonucleotide containing an internal, non-nucleotide-based linker promote site-specific cleavage of RNA.

Authors:  M A Reynolds; T A Beck; P B Say; D A Schwartz; B P Dwyer; W J Daily; M M Vaghefi; M D Metzler; R E Klem; L J Arnold
Journal:  Nucleic Acids Res       Date:  1996-02-15       Impact factor: 16.971

3.  Highly efficient catalytic RNA cleavage by the cooperative action of two Cu(II) complexes embodied within an antisense oligonucleotide.

Authors:  Satoshi Sakamoto; Takashi Tamura; Takako Furukawa; Yasuo Komatsu; Eiko Ohtsuka; Masaya Kitamura; Hideo Inoue
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

4.  Cleavage of tRNA with imidazole and spermine imidazole constructs: a new approach for probing RNA structure.

Authors:  V V Vlassov; G Zuber; B Felden; J P Behr; R Giegé
Journal:  Nucleic Acids Res       Date:  1995-08-25       Impact factor: 16.971

5.  Site-selective artificial ribonucleases: oligonucleotide conjugates containing multiple imidazole residues in the catalytic domain.

Authors:  Natalia G Beloglazova; Martin M Fabani; Nikolai N Polushin; Vladimir V Sil'nikov; Valentin V Vlassov; Elena V Bichenkova; Marina A Zenkova
Journal:  J Nucleic Acids       Date:  2011-09-25
  5 in total

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