Literature DB >> 7882007

Maturation and segregation of brain networks that modify seizures.

S L Moshé1, L L Brown, H Kubová, J Velísková, R S Zukin, E F Sperber.   

Abstract

The mature brain is less susceptible to seizures than the immature brain. We demonstrate that in the mature substantia nigra (SN) there are two topographically discrete GABAA-sensitive regions which differ in the amount of mRNA expression of the GABAA receptor alpha 1 subunit. These two regions mediate separate anticonvulsant and proconvulsant effects and use divergent projection networks. By contrast, in the immature SN there is no special topography of mRNA expression of the alpha 1 subunit and only the proconvulsant network is present. The decreased seizure susceptibility of the mature brain may be related to postnatal segregation of GABAA-sensitive networks.

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Year:  1994        PMID： 7882007     DOI： 10.1016/0006-8993(94)91164-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  10 in total

1.  The expression of GABA(A) receptor subunits in the substantia nigra is developmentally regulated and region-specific.

Authors:  J Velísková; H Kubová; L K Friedman; R Wu; E F Sperber; R S Zukin; S L Moshé
Journal:  Ital J Neurol Sci       Date:  1998-08

Review 2.  Sex dimorphism in seizure-controlling networks.

Authors:  Fillippo Sean Giorgi; Aristea S Galanopoulou; Solomon L Moshé
Journal:  Neurobiol Dis       Date:  2014-05-20       Impact factor: 5.996

3.  Age- and sex-related characteristics of tonic GABA currents in the rat substantia nigra pars reticulata.

Authors:  O Chudomel; H Hasson; M Bojar; S L Moshé; A S Galanopoulou
Journal:  Neurochem Res       Date:  2015-02-03       Impact factor: 3.996

4.  The role of substantia nigra pars reticulata in modulating clonic seizures is determined by testosterone levels during the immediate postnatal period.

Authors:  Filippo S Giorgi; Jana Velísková; Ondrej Chudomel; Andreas Kyrozis; Solomon L Moshé
Journal:  Neurobiol Dis       Date:  2006-09-28       Impact factor: 5.996

5.  Temporal sequence of ictal discharges propagation in the corticolimbic basal ganglia system during amygdala kindled seizures in freely moving rats.

Authors:  Li-Hong Shi; Fei Luo; Donald J Woodward; Dan C McIntyre; Jing-Yu Chang
Journal:  Epilepsy Res       Date:  2006-10-16       Impact factor: 3.045

Review 6.  Mutations affecting GABAergic signaling in seizures and epilepsy.

Authors:  Aristea S Galanopoulou
Journal:  Pflugers Arch       Date:  2010-03-30       Impact factor: 3.657

7.  Regional neural activity within the substantia nigra during peri-ictal flurothyl generalized seizure stages.

Authors:  Jana Velísková; Alexandra M Miller; Magda L Nunes; Lucy L Brown
Journal:  Neurobiol Dis       Date:  2005-06-13       Impact factor: 5.996

8.  Update on the role of substantia nigra pars reticulata in the regulation of seizures.

Authors:  Jana Velísková; Solomon L Moshé
Journal:  Epilepsy Curr       Date:  2006 May-Jun       Impact factor: 7.500

9.  Involvement of the limbic basal ganglia in ethanol withdrawal convulsivity in mice is influenced by a chromosome 4 locus.

Authors:  Gang Chen; Laura B Kozell; Robert Hitzemann; Kari J Buck
Journal:  J Neurosci       Date:  2008-09-24       Impact factor: 6.167

10.  Age- and gender-related differences in GABAA receptor-mediated postsynaptic currents in GABAergic neurons of the substantia nigra reticulata in the rat.

Authors:  O Chudomel; H Herman; K Nair; S L Moshé; A S Galanopoulou
Journal:  Neuroscience       Date:  2009-06-13       Impact factor: 3.590
  10 in total

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