Safe discontinuation of antihypertensive therapy.

We summarize herein the clinical and pathophysiological features of antihypertensive withdrawal syndrome and its risk factors, management, and prevention. Antihypertensive withdrawal syndrome occurs most frequently with beta-blocking agents and centrally acting antihypertensives such as clonidine hydrochloride. This syndrome resembles a state of sympathetic nervous system hyperactivity. In the most critical case, it can be severe and life threatening. Antihypertensive dosages, particularly for beta-blockers and clonidine, should be tapered slowly rather than discontinued abruptly.