Diagnostic and treatment implications of psychiatric comorbidity with migraine.

Although an association between migraine and psychiatric disorders has been recognized for over 100 years, this association has been investigated systematically only recently in clinical and community samples. Mechanisms for comorbidity between migraine and psychopathology have also been examined in recent family, pharmacologic treatment, and challenge studies. We review the evidence of an association between migraine and mood, anxiety, and eating disorders and discuss the implications of this association in the diagnosis and pharmacologic treatment of patients with psychiatric disorders and comorbid migraine.