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Literature DB >> 7881166

Expression of the BMP 2 gene during bone cell differentiation.

N Ghosh-Choudhury¹, M A Harris, J Q Feng, G R Mundy, S E Harris.

Abstract

Bone morphogenetic protein 2 (BMP 2) and transforming growth factor beta (TGF beta) are actively involved in bone formation and remodeling. TGF beta, a powerful stimulant in the early stage of bone cell growth and matrix formation, inhibits differentiation and in vitro mineralized nodule formation in primary fetal rat calvarial osteoblast system. TGF beta also negatively regulates BMP 2 expression at the transcriptional level. BMP 2 gene expression is controlled by a battery of transcriptional factors, some known and some yet to be identified. Immortalized osteoblast cell lines generated from a transgenic mouse carrying BMP 2 promoter-driven SV40 large T antigen transgene are described as powerful tools for studying regulation of BMP 2 gene expression and bone cell differentiation at the molecular level.

Entities: Gene Species

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Year: 1994 PMID： 7881166 DOI： 10.1615/critreveukargeneexpr.v4.i2-3.30

Source DB: PubMed Journal: Crit Rev Eukaryot Gene Expr ISSN： 1045-4403 Impact factor: 1.807

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Cited

15 in total

1. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

Authors: Bing Shu; Ming Zhang; Rong Xie; Meina Wang; Hongting Jin; Wei Hou; Dezhi Tang; Stephen E Harris; Yuji Mishina; Regis J O'Keefe; Matthew J Hilton; Yongjun Wang; Di Chen
Journal: J Cell Sci Date: 2011-10-07 Impact factor: 5.285

2. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.

Authors: Ming Zhao; Mei Qiao; Stephen E Harris; Di Chen; Babatunde O Oyajobi; Gregory R Mundy
Journal: Mol Cell Biol Date: 2006-08 Impact factor: 4.272

Review 3. Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.

Authors: J B Lian; G S Stein
Journal: Iowa Orthop J Date: 1995

4. Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.

Authors: Ernesto Canalis; Kristen Parker; Stefano Zanotti
Journal: J Cell Physiol Date: 2012-01 Impact factor: 6.384

5. c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis.

Authors: Nandini Ghosh-Choudhury; Chandi C Mandal; Falguni Das; Suthakar Ganapathy; Seema Ahuja; Goutam Ghosh Choudhury
Journal: J Biol Chem Date: 2013-07-02 Impact factor: 5.157

Expression of the BMP 2 gene during bone cell differentiation.

1. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.

2. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling.

Review 3. Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation.

4. Gremlin1 is required for skeletal development and postnatal skeletal homeostasis.

5. c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis.

6. Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts.

7. Connective tissue growth factor enhances osteoblastogenesis in vitro.

8. Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.

9. Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts.

10. Kruppel-like factor 5 is required for perinatal lung morphogenesis and function.