Literature DB >> 7880573

Reflections on the consanguinity and birth outcome debate.

W I Ahmad1.   

Abstract

The high rate of consanguineous marriages has been implicated as an important factor in the high rates of perinatal mortality and congenital malformations among the UK Pakistani population. This paper critically considers the debate on consanguinity and birth outcome. A critical review of epidemiological literature is placed in the context of wider, but centrally important, debates on social class and ethnic categorizations, notions of culture and literature on racism. The epidemiological literature is inconsistent in its findings, and is often based on data and arguments of dubious validity. Equally, notions of social class, ethnicity and culture used in such studies lack sophistication and require reconsideration. Health policy options based on promoting cultural change in marriage patterns, conveniently but unjustifiably, shift the blame of poor birth outcome onto the Pakistani community and are doomed to failure. The consanguinity hypothesis is over-simplistic to explain the higher rates of perinatal mortality and congenital malformations among the Pakistani population. Its popularity rests less on its scientific merit and more on its convenience in shifting the blame onto supposedly deviant cultures and marriage patterns and its fit with racist ideas of alienness and deviance.

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Year:  1994        PMID: 7880573     DOI: 10.1093/oxfordjournals.pubmed.a043023

Source DB:  PubMed          Journal:  J Public Health Med        ISSN: 0957-4832


  9 in total

1.  Consanguinity, endogamy, and genetic disorders in Tunisia.

Authors:  Nizar Ben Halim; Nissaf Ben Alaya Bouafif; Lilia Romdhane; Rym Kefi Ben Atig; Ibtissem Chouchane; Yosra Bouyacoub; Imen Arfa; Wafa Cherif; Sonia Nouira; Faten Talmoudi; Khaled Lasram; Sana Hsouna; Welid Ghazouani; Hela Azaiez; Leila El Matri; Abdelmajid Abid; Neji Tebib; Marie-Françoise Ben Dridi; Salem Kachboura; Ahlem Amouri; Mourad Mokni; Saida Ben Arab; Koussay Dellagi; Sonia Abdelhak
Journal:  J Community Genet       Date:  2012-12-04

2.  Quantification of homozygosity in consanguineous individuals with autosomal recessive disease.

Authors:  C Geoffrey Woods; James Cox; Kelly Springell; Daniel J Hampshire; Moin D Mohamed; Martin McKibbin; Rowena Stern; F Lucy Raymond; Richard Sandford; Saghira Malik Sharif; Gulshan Karbani; Mustaq Ahmed; Jacquelyn Bond; David Clayton; Chris F Inglehearn
Journal:  Am J Hum Genet       Date:  2006-03-21       Impact factor: 11.025

3.  UK Pakistani views on the adverse health risks associated with consanguineous marriages.

Authors:  Mubasshir Ajaz; Nasreen Ali; Gurch Randhawa
Journal:  J Community Genet       Date:  2015-02-06

4.  Population stratification and genetic association studies in South Asia.

Authors:  Alan H Bittles
Journal:  J Mol Genet Med       Date:  2005-12-30

Review 5.  Muslim patients and health disparities in the UK and the US.

Authors:  Lance D Laird; Mona M Amer; Elizabeth D Barnett; Linda L Barnes
Journal:  Arch Dis Child       Date:  2007-10       Impact factor: 3.791

6.  Community engagement and education: addressing the needs of South Asian families with genetic disorders.

Authors:  Nasaim Khan; Gifford Kerr; Helen Kingston
Journal:  J Community Genet       Date:  2016-09-10

7.  Novel C8orf37 mutations cause retinitis pigmentosa in consanguineous families of Pakistani origin.

Authors:  Zeinab Ravesh; Mohammed E El Asrag; Nicole Weisschuh; Martin McKibbin; Peggy Reuter; Christopher M Watson; Britta Baumann; James A Poulter; Sundus Sajid; Evangelia S Panagiotou; James O'Sullivan; Zakia Abdelhamed; Michael Bonin; Mehdi Soltanifar; Graeme C M Black; Muhammad Amin-ud Din; Carmel Toomes; Muhammad Ansar; Chris F Inglehearn; Bernd Wissinger; Manir Ali
Journal:  Mol Vis       Date:  2015-03-07       Impact factor: 2.367

8.  Screening of 31 genes involved in monogenic forms of obesity in 23 Pakistani probands with early-onset childhood obesity: a case report.

Authors:  Robina Khan Niazi; Anette Prior Gjesing; Mette Hollensted; Christian Theil Have; Dmitrii Borisevich; Niels Grarup; Oluf Pedersen; Asmat Ullah; Gulbin Shahid; Ifrah Shafqat; Asma Gul; Torben Hansen
Journal:  BMC Med Genet       Date:  2019-09-05       Impact factor: 2.103

9.  What factors predict differences in infant and perinatal mortality in primary care trusts in England? A prognostic model.

Authors:  Nick Freemantle; J Wood; C Griffin; P Gill; M J Calvert; A Shankar; J Chambers; C MacArthur
Journal:  BMJ       Date:  2009-08-04
  9 in total

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