| Literature DB >> 7880450 |
S L Cappendijk1, D Fekkes, M R Dzoljic.
Abstract
Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded that both norharman and ibogaine are inhibitors of withdrawal syndrome in morphine-dependent rats.Entities:
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Year: 1994 PMID： 7880450 DOI： 10.1016/0166-4328(94)90080-9
Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332