Literature DB >> 7880236

Adverse interaction between warfarin and indomethacin.

T Y Chan1, S F Lui, S Y Chung, S Luk, J A Critchley.   

Abstract

A 57-year-old man developed spontaneous skin bruising and haematuria during combined therapy with warfarin and indomethacin. Due to the potential effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the anticoagulant action of warfarin and platelet function, patients receiving both warfarin and NSAIDs should have their prothrombin time monitored very closely. Also, the risk of gastrointestinal haemorrhage with any NSAIDs must always be remembered.

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Year:  1994        PMID: 7880236     DOI: 10.2165/00002018-199410030-00006

Source DB:  PubMed          Journal:  Drug Saf        ISSN: 0114-5916            Impact factor:   5.606


  9 in total

1.  Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard.

Authors:  A S Yip; W H Chow; Y T Tai; K L Cheung
Journal:  Postgrad Med J       Date:  1990-05       Impact factor: 2.401

2.  Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy.

Authors:  C S Landefeld; L Goldman
Journal:  Am J Med       Date:  1989-08       Impact factor: 4.965

3.  Failure of indomethacin and warfarin to interact in normal human volunteers.

Authors:  E S Vesell; G T Passananti; A O Johnson
Journal:  J Clin Pharmacol       Date:  1975-07       Impact factor: 3.126

Review 4.  Interaction between oral anti-coagulant drugs and non-steroidal anti-inflammatory agents: a review.

Authors:  T Pullar; H A Capell
Journal:  Scott Med J       Date:  1983-01       Impact factor: 0.729

5.  Combining NSAIDs with anticoagulants: yes and no.

Authors:  J W O'Callaghan; R N Thompson; A S Russell
Journal:  Can Med Assoc J       Date:  1984-10-15       Impact factor: 8.262

6.  Letter: Drug enhancement of warfarin activity.

Authors:  T H Self; W E Evans; T Ferguson
Journal:  Lancet       Date:  1975-09-20       Impact factor: 79.321

7.  Potentiation of anticoagulants.

Authors:  B I Hoffbrand; D A Kininmonth
Journal:  Br Med J       Date:  1967-06-24

8.  Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients.

Authors:  J Launbjerg; H Egeblad; J Heaf; N H Nielsen; A M Fugleholm; K Ladefoged
Journal:  J Intern Med       Date:  1991-04       Impact factor: 8.989

9.  Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions.

Authors:  C S Landefeld; M W Rosenblatt; L Goldman
Journal:  Am J Med       Date:  1989-08       Impact factor: 4.965

  9 in total
  4 in total

1.  Adverse interaction between warfarin and indomethacin.

Authors:  R Day; D Quinn
Journal:  Drug Saf       Date:  1994-09       Impact factor: 5.606

Review 2.  Drug Interactions Affecting Oral Anticoagulant Use.

Authors:  Philip L Mar; Rakesh Gopinathannair; Brooke E Gengler; Mina K Chung; Arturo Perez; Jonathan Dukes; Michael D Ezekowitz; Dhanunjaya Lakkireddy; Gregory Y H Lip; Mike Miletello; Peter A Noseworthy; James Reiffel; James E Tisdale; Brian Olshansky
Journal:  Circ Arrhythm Electrophysiol       Date:  2022-05-27

Review 3.  Clinically important drug interactions with anticoagulants. An update.

Authors:  S Harder; P Thürmann
Journal:  Clin Pharmacokinet       Date:  1996-06       Impact factor: 6.447

Review 4.  Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs.

Authors:  J R Brouwers; P A de Smet
Journal:  Clin Pharmacokinet       Date:  1994-12       Impact factor: 6.447

  4 in total

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