OBJECTIVES: To investigate the time course of a monoarthritis induced with the purified protein derivative of tuberculin (PPD) or a recombinant 65 kDa heat shock protein (rhsp65) in two different strains of sensitised rats. METHODS: Wistar and Lewis rats, sensitised with heat killed Mycobacterium tuberculosis in oil, were challenged intraarticularly with PPD or rhsp65 and monitored for six weeks. Inflammation was assessed by joint swelling, histology, and radiographic studies. RESULTS: Sensitised Lewis rats injected with PPD or rhsp65 showed a chronic response with recurrent spontaneous flares, while Wistar rats showed one inflammatory episode. CONCLUSIONS: The Wistar strain response to PPD resembles a transient reactive arthritis, while the response of the Lewis strain mimics the relapsing nature of rheumatoid synovitis, providing an interesting model to determine dominant immunopathogenic mechanisms.
OBJECTIVES: To investigate the time course of a monoarthritis induced with the purified protein derivative of tuberculin (PPD) or a recombinant 65 kDa heat shock protein (rhsp65) in two different strains of sensitised rats. METHODS: Wistar and Lewis rats, sensitised with heat killed Mycobacterium tuberculosis in oil, were challenged intraarticularly with PPD or rhsp65 and monitored for six weeks. Inflammation was assessed by joint swelling, histology, and radiographic studies. RESULTS: Sensitised Lewis rats injected with PPD or rhsp65 showed a chronic response with recurrent spontaneous flares, while Wistar rats showed one inflammatory episode. CONCLUSIONS: The Wistar strain response to PPD resembles a transient reactive arthritis, while the response of the Lewis strain mimics the relapsing nature of rheumatoid synovitis, providing an interesting model to determine dominant immunopathogenic mechanisms.
Authors: J S Gaston; P F Life; K Granfors; R Merilahti-Palo; L Bailey; S Consalvey; A Toivanen; P A Bacon Journal: Clin Exp Immunol Date: 1989-06 Impact factor: 4.330
Authors: W van Eden; J E Thole; R van der Zee; A Noordzij; J D van Embden; E J Hensen; I R Cohen Journal: Nature Date: 1988-01-14 Impact factor: 49.962
Authors: V R Winrow; S Ragno; C J Morris; M J Colston; P Mascagni; F Leoni; G Gromo; A R Coates; D R Blake Journal: Ann Rheum Dis Date: 1994-03 Impact factor: 19.103
Authors: E M Sternberg; J M Hill; G P Chrousos; T Kamilaris; S J Listwak; P W Gold; R L Wilder Journal: Proc Natl Acad Sci U S A Date: 1989-04 Impact factor: 11.205
Authors: P C Res; C G Schaar; F C Breedveld; W van Eden; J D van Embden; I R Cohen; R R de Vries Journal: Lancet Date: 1988-08-27 Impact factor: 79.321