A cognitive model for schizophrenia and its possible neural basis.

It is proposed that the basic disturbance in schizophrenia corresponds to a disruption of the normal relationship between stored material and current sensory input. The link between information processing disturbances and their biological bases may be facilitated by the use of paradigms derived from animal learning theory. A model for the emergence of schizophrenic symptoms is presented. The core cognitive abnormality may result from a disturbance at any point in the neural circuit involved in the prediction of subsequent sensory input.