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[The mechanisms of the formation of neuronal reactions in the cat motor cortex related to the initiation of a conditioned reflex of the placing of a limb on a support: hypothesis].

Abstract

Excitatory reactions of the motor cortex neurons during initiation of the conditioned placing are supposed to be based on NMDA receptor activation. The conditions needed for the NMDA receptor-driven channels to be opened by glutamate (mainly, postsynaptic hyperpolarization neutralization), are provided by the conditioned "arousal reaction" through the augmentation of cholinergic/noradrenergic bombardment of the motor cortex neurons.

Entities: Chemical

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Year: 1994 PMID： 7879450

Source DB: PubMed Journal: Zh Vyssh Nerv Deiat Im I P Pavlova ISSN： 0044-4677 Impact factor: 0.437

[The mechanisms of the formation of neuronal reactions in the cat motor cortex related to the initiation of a conditioned reflex of the placing of a limb on a support: hypothesis].

1. The facilitatory and depressive effects of iontophoretically applied acetylcholine on different components of neuron responses in the motor cortex of the cat during performance of a conditioned paw positioning reflex.

2. The role of the cholinergic system of the sensorimotor cortex of the rat brain in controlling different types of movement.

3. Network activity in neurons of the motor and prefrontal areas of the cortex in trained cats in conditions of systemic administration of m-cholinoreceptor blockers.

4. Effect of 2-amino-5-phosphopentanoic acid (AP5), a glutamate NMDA receptor blocker, on neuron activity in the cat motor cortex during performance of a paw placement conditioned reflex.