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Literature DB >> 7878739

The clot thickens: clues provided by thrombin structure.

Abstract

Thrombin is the primary promoter of blood clotting; it also plays an important role in the regulation of the coagulation cascade and has been implicated in a number of other cellular processes. How can one molecule catalyse such a variety of events? The recent X-ray structure determination of human a-thrombin and related structures shows that the molecule can be divided into several functional regions that recognize different chemical moieties. By using different combinations of these elements, thrombin can interact with a variety of macromolecules with high specificity.

Entities: Gene Species

Mesh：

Substances：
Thrombin

Year: 1995 PMID： 7878739 DOI： 10.1016/s0968-0004(00)88945-8

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

31 in total

1. Counteracting effect of glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom.

Authors: Mariane Assafim; Marcos S Ferreira; Flávia S Frattani; Jorge A Guimarães; Robson Q Monteiro; Russolina B Zingali
Journal: Br J Pharmacol Date: 2006-06-05 Impact factor: 8.739

2. Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding.

Authors: Sherri Rinker; Yonggang Ke; Yan Liu; Rahul Chhabra; Hao Yan
Journal: Nat Nanotechnol Date: 2008-06-22 Impact factor: 39.213

Review 3. Functional nucleic acid sensors.

Authors: Juewen Liu; Zehui Cao; Yi Lu
Journal: Chem Rev Date: 2009-05 Impact factor: 60.622

4. Crystal structure of an RNA aptamer bound to thrombin.

Authors: Stephen B Long; Meredith B Long; Rebekah R White; Bruce A Sullenger
Journal: RNA Date: 2008-10-29 Impact factor: 4.942

5. Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V.

Authors: Harlan N Bradford; Sriram Krishnaswamy
Journal: J Biol Chem Date: 2018-12-21 Impact factor: 5.157

6. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.

Authors: P Fuentes-Prior; C Noeske-Jungblut; P Donner; W D Schleuning; R Huber; W Bode
Journal: Proc Natl Acad Sci U S A Date: 1997-10-28 Impact factor: 11.205

The clot thickens: clues provided by thrombin structure.

1. Counteracting effect of glycyrrhizin on the hemostatic abnormalities induced by Bothrops jararaca snake venom.

2. Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding.

Review 3. Functional nucleic acid sensors.

4. Crystal structure of an RNA aptamer bound to thrombin.

5. Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V.

6. Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.

Review 7. The transition of prothrombin to thrombin.

Review 8. Thrombin inhibitors from different animals.

9. Structural and kinetic determinants of protease substrates.

10. Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase.