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Literature DB >> 7877979

p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus.

A Puisieux¹, J Ji, C Guillot, Y Legros, T Soussi, K Isselbacher, M Ozturk.

Abstract

Wild-type p53 acts as a tumor suppressor gene by protecting cells from deleterious effects of genotoxic agents through the induction of a G1/S arrest or apoptosis as a response to DNA damage. Transforming proteins of several oncogenic DNA viruses inactivate tumor suppressor activity of p53 by blocking this cellular response. To test whether hepatitis B virus displays a similar effect, we studied the p53-mediated cellular response to DNA damage in 2215 hepatoma cells with replicative hepatitis B virus. We demonstrate that hepatitis B virus replication does not interfere with known cellular functions of p53 protein.

Entities: Disease Gene Species

Mesh：

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Year: 1995 PMID： 7877979 PMCID： PMC42515 DOI： 10.1073/pnas.92.5.1342

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

44 in total

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13 in total

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Journal: J Biol Chem Date: 2019-07-30 Impact factor: 5.157

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Authors: Updesh Dixit; Ashutosh K Pandey; Zhihe Liu; Sushil Kumar; Matthew B Neiditch; Kenneth M Klein; Virendra N Pandey
Journal: J Virol Date: 2015-05-20 Impact factor: 5.103

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