Literature DB >> 7877449

Increased fearfulness of Fyn tyrosine kinase deficient mice.

T Miyakawa1, T Yagi, S Watanabe, H Niki.   

Abstract

Fyn-deficient mice were produced by inserting the beta-galactosidase gene (lacZ) into the fyn gene locus. The homozygously Fyn kinase-deficient (fynz/fynz) mice exhibited stronger light aversion in the light-dark choice test and higher fear-response scores in the novelty preference and passive avoidance tests than did the heterozygously Fyn-deficient (+/fynz) mice. These results indicate that fynz/fynz mice are hyperresponsive to fear-inducing stimuli.

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Year:  1994        PMID： 7877449     DOI： 10.1016/0169-328x(94)90201-1

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  17 in total

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