Molecular diversity at the carboxyl terminus of human and rat tau.

Although a long terminal isoform of tau was historically the first identified clone, no such isform has been thus far reported among species other than mouse. We show here that there are homologues of the long terminal isoform in human and rat, but in various forms in contrast to mouse. There are generated by a combination of multiple splice sites, which causes distinct molecular diversity at the carboxyl terminus of human and rat tau.