| Literature DB >> 7876674 |
K Kono1, I Tatara, S Takeda, K Arakawa, Y Hara.
Abstract
The antibacterial activity of epigallocatechin gallate (EGCg), a catechin, against 53 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) was evaluated and expressed as minimal inhibitory concentration (MIC). The MIC50 and MIC90 of the strains were found be 64 and 126 micrograms/ml, respectively by the microdilution method. A time-kill study using an isolate showed that EGCg appeared to be bacteriostatic at 1-2 x MIC and bactericidal at 6 x MIC against MRSA. In addition, the activity of EGCg was stable to various physical conditions including boiling or freezing. These findings suggest that EGCg could be a useful agent for treating MRSA infection.Entities:
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Year: 1994 PMID： 7876674 DOI： 10.11150/kansenshogakuzasshi1970.68.1518
Source DB: PubMed Journal: Kansenshogaku Zasshi ISSN： 0387-5911