Literature DB >> 7875612

An additional 5'-upstream exon exists in the human pleiotrophin-encoding gene.

S Lai1, A M Schulte, A Wellstein, A T Riegel.   

Abstract

A 2-kb 5' fragment of hPTN (human pleiotrophin-encoding) genomic DNA was sequenced. Within this region we identified a new, upstream exon (U2). Cloning and sequencing of the PCR products of cDNAs from a human melanoma cell line revealed that a 401-bp intron was spliced out between exon U2 and a previously described untranslated exon U1. Our analysis also revealed that previously reported transcription start points (tsp) of PTN are located within exon U1.

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Year:  1995        PMID： 7875612     DOI： 10.1016/0378-1119(94)00674-h

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  2 in total

1.  Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus.

Authors:  A M Schulte; S Lai; A Kurtz; F Czubayko; A T Riegel; A Wellstein
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

Review 2.  Molecular and pharmacologic targeting of angiogenesis factors--the example of pleiotrophin.

Authors:  F Czubayko; A M Schulte; S C Missner; S S Hsieh; K J Colley; A Wellstein
Journal:  Breast Cancer Res Treat       Date:  1995       Impact factor: 4.872
  2 in total

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